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MetabolomicsMaize Recruits Beneficial Microorganisms via Rhizosphere Metabolites as Signals to Construct a Functional Network for Saline-Alkaline Stress Resistance

Carbonate-type saline-alkaline stress severely constrains maize production; however, the synergistic response mechanisms between rhizosphere microorganisms and metabolites remain unclear. This study focused on maize fields in the carbonate chernozem region of the Songnen Plain in Northeast China....

2026-06-08 | MTBLS13956 | MetaboLights
MetabolomicsMulti-omics reveals that alkaline mineral water improves the respiratory health and growth performance of transported calves

BACKGROUND: Long-distance transportation, a frequent practice in the cattle industry, stresses calves and results in morbidity, mortality and growth suppression, leading to welfare concerns and economic losses. Alkaline mineral water (AMW) is an electrolyte additive containing mu...

2024-06-04 | MTBLS8204 | MetaboLights
TranscriptomicsSevere alkaline pH stress induces a glucose starvation-related transcriptional response in S. cerevisiae
Alkaline pH stress invokes in S. cerevisiae a potent and fast transcriptional response that includes many genes repressed by glucose. Certain mutants in the glucose-sensing and response pathways, such as those lacking the Snf1 kinase, are sensitive to alkalinization. We show that addition of glucose...
ORGANISM(S): Saccharomyces cerevisiae 
2012-03-02 | E-GEOD-25697 | biostudies-arrayexpress
MetabolomicsMulti-Omics Reveals that Alkaline Mineral Complex Enhances Nutrient Digestion–Absorption and Gut Health

This study, conducted under a high-concentrate finishing context, used an integrated multi-omics approach to evaluate the effects of an Alkaline Mineral Complex (AMC) on jejunal digestion–absorption and gut health in beef cattle. The results showed that AMC alleviated mucosal pathological injury ...

2026-07-14 | MTBLS13175 | MetaboLights
ProteomicsOnline alkaline-pH reverse phase nanoelectrospray-tandem mass spectrometry complements conventional low-pH method for global proteomic analysis
The global proteome analysis was limited by the identification of peptides with low abundance or specific physiochemical properties. Here, a one-dimensional online alkaline-pH reverse phase nanoelectrospray-tandem mass spectrometry (AlkalinepH-MS/MS) method was developed and optimized for global pro...
ORGANISM(S): Homo Sapiens 
2023-01-15 | PXD039453 |
TranscriptomicsToxoplasma gondii lysine acetyltransferase GCN5-A functions in the cellular response to alkaline stress and expression of cyst genes
Parasitic protozoa such as the apicomplexan Toxoplasma gondii progress through their life cycle in response to stimuli in the environment or host organism. Very little is known about how proliferating tachyzoites reprogram their expressed genome in response to stresses that prompt development into ...
ORGANISM(S): Toxoplasma gondii 
2011-05-25 | E-GEOD-22100 | biostudies-arrayexpress
ProteomicsProteomics investigation into the alkaline pH-driven metabolic plasticity of Lactococcus lactis FM03
This study investigates the proteomic changes underpinning the adaptation mechanisms of Lactococcus lactis subsp. lactis biovar diacetylactis FM03 under alkaline pH.
ORGANISM(S): Lactococcus lactis subsp. lactis bv. diacetylactis 
2025-10-27 | PXD065893 | Pride
Chemostat High ph Metabolic shift Lactic acid bacteria Resource allocation 
TranscriptomicsHUVECs with endogenous or overexpressed GPR4 treated with pH 8.4 (control) or pH 6.4 for 5 h
Acidic tissue microenvironment is commonly found in a variety of pathophysiological conditions. GPR4 is a proton-sensing G protein-coupled receptor that is fully activated by acidic extracellular pH but has lesser activity at the physiological pH 7.4 and minimal activity at more alkaline pH. To dete...
ORGANISM(S): Homo sapiens 
2013-04-25 | E-GEOD-40060 | biostudies-arrayexpress
ProteomicsAcclimation of Synechocystis sp. PCC 6803 to alkaline pH under ambient air
Cyanobacteria are able to grow at a wide pH range and for many strains their growth is enhanced in alkaline environment. In this study, we investigated the proteomic response of the cyanobacterium of Synechocystis sp. PCC 6803 to alkaline pH. The proteomes of Synechocystis grown in BG-11 medium buff...
ORGANISM(S): Synechocystis sp. (strain PCC 6803 / Kazusa) 
2025-09-04 | PXD061233 | Pride
Lc-msms Cyanobacterium Ph 
ModelsAl-Husari2013 - pH and lactate in tumor
The paper describes a model of pH control in tumor. Created by COPASI 4.26 (Build 213) This model is described in the article: Regulation of tumour intracellular pH: A mathematical model examining the interplay between H and lactate Maymona Al-Husari, Steven D. Webb Journal of Theoretical Biolog...
2024-09-02 | BIOMD0000000805 | BioModels
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