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Multi-omics analysis revealed the pathogenetic mechanisms of Mechanical allodynia in type 1 diabetes
We used microarray-based expression genomics in 25 inbred mouse strains to identify dorsal root ganglion (DRG)-expressed genetic contributors to mechanical allodynia a prominent symptom of chronic pain. Expression genetics identifies a role for the Chrna6 (alpha 6-nicotinic receptor) gene in pain in...
ORGANISM(S): Mus musculus 
Neuropathic pain is an apparently spontaneous experience triggered by abnormal physiology of the peripheral or central nervous system, which evolves with time. Neuropathic pain arising from peripheral nerve injury is characterized by a combination of spontaneous pain, hyperalgesia and allodynia. The...
ORGANISM(S): Rattus norvegicus 
MicroRNA-96 is required to prevent allodynia by repressing voltage-gated sodium channels in spinal cord
Boldine Attenuates Mechanical Allodynia and Mitigates Transcriptomic Changes in a Mouse Model of Chronic Constriction Injury
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