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GenomicsReceptor Allostery Promotes Sonic Hedgehog Signaling During Embryonic Development
Receptor Allostery Promotes Sonic Hedgehog Signaling During Embryonic Development
PRJNA1196536 | ENA
ProteomicsEngineering and exploiting synthetic allostery of NanoLuc luciferase
The ability to endow constitutively active proteins with synthetic allostery is a central objective of Synthetic Biology, mostly focused on the creation of protein biosensors – artificial sensing proteins with easily quantifiable outputs. Here we hypothesize that circular permutation of proteins inc...
ORGANISM(S): Escherichia coli 
2022-02-10 | PXD031169 | Pride
Lc-ms Hdmse Hdx Biosenso Allostery 
MetabolomicsProtein-metabolite interactomics of carbohydrate metabolism reveal regulation of lactate dehydrogenase

Metabolic networks are interconnected and influence diverse cellular processes. The protein-metabolite interactions that mediate these networks are frequently low affinity and challenging to systematically discover. We developed mass spectrometry integrated with equilibrium dialysis for the disco...

2023-08-07 | MTBLS7237 | MetaboLights
GenomicsGenetics, energetics, and allostery in proteins with randomized cores and surfaces
Genetics, energetics, and allostery in proteins with randomized cores and surfaces
PRJNA1106529 | ENA
ModelsStefan2008 - calmodulin allostery
Stefan2008 - calmodulin allostery An allosteric model for calmodulin activation, in which binding to calcium facilitates the transition between a low-affinity [tense (T)] and a high-affinity [relaxed (R)] state. This model is described in the article: An allosteric model o...
2024-09-02 | BIOMD0000000183 | BioModels
UnknownProtein Allostery at Atomic Resolution.
Not available
S-EPMC9202374 | biostudies-literature
OtherGenetics, energetics, and allostery in proteins with randomized cores and surfaces
A lack of systematic experimental data limits our understanding of protein evolution. In this study, we experimentally characterized proteins with randomized sequences. Vast numbers of amino acid combinations constitute stable protein cores and surfaces. However, alternative cores frequently disrupt...
ORGANISM(S): Saccharomyces cerevisiae 
2024-05-13 | GSE266299 | GEO
TranscriptomicsReceptor Allostery Promotes Sonic Hedgehog Signaling During Embryonic Development
Sonic Hedgehog (SHH) signaling functions in temporal and context-dependent manners to pattern diverse tissues during embryogenesis. The signal transducer Smoothened (SMO) is regulated by sterols, oxysterols, and arachidonic acid (AA) through binding pockets in its extracellular cysteine rich domain ...
ORGANISM(S): Mus musculus 
2025-02-26 | GSE283994 | GEO
UnknownAllostery through DNA drives phenotype switching.
Not available
S-EPMC8170675 | biostudies-literature
UnknownDynamically driven protein allostery.
Not available
S-EPMC2757644 | biostudies-literature
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