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MetabolomicsRegulatory actors and alternative routes for Arabidopsis seed germination are revealed using a pathway‐based analysis of transcriptomic datasets
Regulation of seed germination by dormancy relies on a complex network of transcriptional and post‐transcriptional modifications during seed imbibition that controls seed adaptive responses to environmental cues. High‐throughput technologies have brought significant progress in the understanding of ...
2019-05-21 | MTBLS662 | MetaboLights
TranscriptomicsThe alternative complement pathway appears to be a UVA sensor that leads to systemic immunosuppression
Ultraviolet (UV) wavebands in sunlight are immunomodulatory. About half the amount of UVA within a minimum erythemal dose of sunlight is systemically immunosuppressive, while higher doses protect from UVB immunosuppression in mice. We have previously shown that these responses to UVA are genetically...
ORGANISM(S): Mus musculus 
2010-05-16 | E-GEOD-15618 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of alternative splicing events regulated by SRSF10 reveals position-dependent splicing modulation.
Splicing factor SRSF10 is known to function as a sequence-specific splicing activator. Here, we used RNA-seq coupled with bioinformatics analysis to identify the extensive splicing network regulated by SRSF10 in chicken cells. We found that SRSF10 promoted both exon inclusion and exclusion. Function...
ORGANISM(S): Gallus gallus 
2014-01-22 | E-GEOD-53354 | biostudies-arrayexpress
TranscriptomicsRegulation of Vertebrate Nervous System-Specific Alternative Splicing and Development by an SR-Related Protein
Alternative splicing is a key process underlying the evolution of increased proteomic and functional complexity and is especially prevalent in the mammalian nervous system. However, the factors and mechanisms governing nervous system-specific alternative splicing are not well understood. Through a g...
ORGANISM(S): Mus musculus 
2010-05-15 | E-GEOD-16187 | biostudies-arrayexpress
TranscriptomicsNext generation sequencing reveals gene transcription activities and alternative splicing events in germinating barley embryos
Seed germination triggers a transition of growth and metabolic activities from quiescent to active statuses. Germinating seeds is a good system to study many biological and biochemical processes including hormone metabolic activities and cell wall biosynthesis. Next generation sequence technology is...
ORGANISM(S): Hordeum vulgare subsp. vulgare 
2016-02-18 | E-GEOD-66024 | biostudies-arrayexpress
TranscriptomicsGlobal analysis of alternative splicing regulation by insulin and wingless signalling in Drosophila cells
Background: Despite the prevalence and biological relevance of both signalling pathways and alternative pre-mRNA splicing, our knowledge of how intracellular signalling impacts on alternative splicing regulation remains fragmentary. We report a genome-wide analysis of changes in alternative splicing...
ORGANISM(S): Drosophila melanogaster 
2010-05-06 | E-GEOD-14085 | biostudies-arrayexpress
TranscriptomicsRegulation of NUMB alternative splicing by RBM5, RBM6 and RBM10 controls cancer cell proliferation
RBM5, a regulator of alternative splicing of apoptotic genes, and its close homologues, RBM6 and RBM10, are RNA binding proteins frequently deleted or mutated in lung cancer. We report that RBM5/6 and RBM10 antagonistically regulate the proliferative capacity of cancer cells and display distinct pos...
ORGANISM(S): Homo sapiens 
2013-12-20 | E-GEOD-47431 | biostudies-arrayexpress
ProteomicsAlternative splicing of Arabidopsis G6PD5 can recruits the NADPH-producing OPPP reactions to the endoplasmic reticulum
Glucose-6-phosphate dehydrogenase is the rate-limiting enzyme of the oxidative pentose-phosphate pathway (OPPP). The OPPP mainly provides NADPH and sugar-phosphate building blocks for anabolic pathways and is present in all eukaryotes. In plant cells, the irreversible part of the OPPP is found in se...
ORGANISM(S): Arabidopsis Thaliana (mouse-ear Cress) 
2022-07-11 | PXD035221 | JPOST Repository
ModelsCaruso2020 - Alternative Complement Pathway model
SBML export of the Alternative Complement Pathway model published by Caruso et al. 2020
2022-06-27 | MODEL2206230002 | BioModels
TranscriptomicsThe Akt-SRPK-SR axis constitutes a major pathway in transducing EGF signaling to regulate alternative splicing in the nucleus
Pre-mRNA splicing is regulated by developmental and environmental cues, but little is known about how specific signals are transduced in mammalian cells to regulate this critical gene expression step. Here, we report massive reprogramming of alternative splicing in response to EGF signaling. By blo...
ORGANISM(S): Homo sapiens 
2012-08-17 | E-GEOD-37731 | biostudies-arrayexpress
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