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ProteomicsAntagonistic roles of canonical and alternative-RPA in disease-associated tandem CAG repeat instability
Ongoing CAG expansions in Spinocerebellar ataxia type 1 (SCA1) and Huntington disease (HD) brains exacerbate disease.  Expansions involve aberrant repair of mutagenic slipped-DNAs, formed from single-stranded DNAs.  Whether singlestranded DNA-binding proteins prevent or facilitate expansions is unkn...
ORGANISM(S): Homo sapiens (Human) 
2023-10-13 | PXD044158 | Pride
Cag repeat expansion diseases  spinocerebellar ataxia type 1 (sca1)  huntington's disease (hd)  somatic cag repeat expansions  rpa (single-strand dna binding protein  alternative-rpa (alt-rpa)  dna repair Slipped-dnas  post-mortem brains Sca1 mice 
UnknownThe helicase domain of Polθ counteracts RPA to promote alt-NHEJ.
Not available
S-EPMC6047744 | biostudies-literature
UnknownAntagonistic roles of canonical and Alternative-RPA in disease-associated tandem CAG repeat instability.
Not available
S-EPMC11209935 | biostudies-literature
UnknownORCA/LRWD1 Regulates Homologous Recombination at ALT-Telomeres by Modulating Heterochromatin Organization.
Not available
S-EPMC7186530 | biostudies-literature
OtherRPA and Rad27 limit templated and inverted insertions at DNA breaks
Formation of templated insertions at DNA double-strand breaks (DSBs) is very common in cancer cells. The mechanisms and enzymes regulating these events are largely unknown. Here, we investigated templated insertions in yeast at DSBs using amplicon sequencing across a repaired locus. We document very...
ORGANISM(S): Saccharomyces cerevisiae 
2024-03-07 | GSE260753 | GEO
UnknownAlternative lengthening of telomeres renders cancer cells hypersensitive to ATR inhibitors.
Not available
S-EPMC4358324 | biostudies-literature
UnknownReplication protein A prevents accumulation of single-stranded telomeric DNA in cells that use alternative lengthening of telomeres.
Not available
S-EPMC2175364 | biostudies-literature
UnknownNHP2 downregulation counteracts hTR-mediated activation of the DNA damage response at ALT telomeres.
Not available
S-EPMC7957427 | biostudies-literature
UnknownBRCA2 antagonizes classical and alternative nonhomologous end-joining to prevent gross genomic instability.
Not available
S-EPMC5684403 | biostudies-literature
UnknownClustered telomeres in phase-separated nuclear condensates engage mitotic DNA synthesis through BLM and RAD52.
Not available
S-EPMC6601508 | biostudies-literature
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