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MetabolomicsFunctional Remodeling of iNKT Cells by Sulfatide-Reactive Type II NKT Cells Reprograms Alveolar Macrophages to Alleviate Lung Ischemia-Reperfusion Injury

Lung ischemia-reperfusion injury (LIRI) is a serious complication in critical clinical situations. Despite its importance, the specific role of type II natural killer T (NKT) cells in LIRI remains unclear. In this study, we establish a LIRI mouse model and demonstrate that sulfatide-reactive type...

2025-12-19 | MTBLS13533 | MetaboLights
ProteomicsDifferential protein expression in the alveolar bone tissue of rats with apical periodontitis
The iTRAQ method was used to analyze differences in protein expression in alveolar bone tissue during the progression of apical periodontitis in rats.
ORGANISM(S): Rattus Norvegicus 
2025-01-16 | PXD059854 |
ProteomicsThe role of Type VI collagen in alveolar bone
In this study, an α2(VI) deficient mouse (Col6α2-KO) model was used to examine the role of Type VI collagen in oral tissues. To examine bone properties, µCT was employed, and bone volume and bone mineral density (BMD) was measured in oral tissues. To further investigate its molecular basis, proteome...
ORGANISM(S): Mus musculus (Mouse) 
2022-11-21 | PXD037422 | Pride
Type vi collagen  µct analysis  proteome analysis   alveolar bone 
TranscriptomicsMouse GM-CSF-related alveolar macrophage genome-wide expression data
GM-CSF receptor-β deficient (Csf2rb–/– or KO) mice develop a lung disease identical to hereditary pulmonary alveolar proteinosis (hPAP) in humans with recessive CSF2RA or CSF2RB mutations that impair GM-CSF receptor function. We performed pulmonary macrophage transplantation (PMT) of bone marro...
ORGANISM(S): Mus musculus 
2014-10-01 | E-GEOD-60528 | biostudies-arrayexpress
MetabolomicsGut Microbiota Dysbiosis and Hypercholesterolemia Are Associated with Bone Metastasis in Non-Small Cell Lung Cancer
We collected baseline fecal samples from 85 patients with newly diagnosed lung cancer, 51 patients with bone metastasis (M group), and 34 patients without bone metastasis (N group). We conducted metagenomic and metabolomic sequencing to compare the differences in gut microbiota and metabolites betwe...
2026-07-10 | MTBLS15004 | MetaboLights
ProteomicsProteomic analysis of human alveolar bone
We optimised a sample preparation and analysis workflow for proteomic analysis of human alveolar bone. We compared the peptides and proteins extracted from bone by different buffers, then used a multi-enzyme, multi-search engine approach to increase proteome coverage.
ORGANISM(S): Homo sapiens (Human) 
2019-11-27 | PXD011524 | Pride
Human Bone Tails Shotgun Missing protein 
ProteomicsInsights into pulmonary phosphate homeostasis and osteoclastogenesis emerge from the study of pulmonary alveolar microlithiasis
Pulmonary alveolar microlithiasis is an autosomal recessive lung disease caused by a deficiency in the pulmonary epithelial Npt2b sodium-phosphate co-transporter that results in accumulation of phosphate and formation of hydroxyapatite microliths in the alveolar space. The single cell transcriptomic...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2023-02-16 | MSV000091302 | MassIVE
TranscriptomicsMicroarray studies on effect of Pneumocystis carinii infection on global gene expression in alveolar macrophages
With a filter of false-discovery rate less than 0.1 and fold change greater than 1.5, 115 genes were found to be up- and 137 were down-regulated in alveolar macrophages during Pneumocystis carinii infection. Total RNA samples from 4 each of normal, dexamethasone-treated, and Pneumocystis carinii-inf...
ORGANISM(S): Rattus norvegicus 
2010-04-12 | E-GEOD-20149 | biostudies-arrayexpress
TranscriptomicsImmunoproteasome dysfunction augments alternative polarization of alveolar macrophages
The proteasome is a central regulatory hub for intracellular signaling by degrading numerous signaling mediators. Immunoproteasomes are specialized types of proteasomes known to be involved in shaping adaptive immune responses, but their role for innate immune signaling is elusive. Here, we analyzed...
ORGANISM(S): Mus musculus 
2016-06-29 | E-GEOD-72000 | biostudies-arrayexpress
TranscriptomicsCigarette smoking alters mRNA expression in human alveolar macrophages
Alveolar macrophages from never smokers and active smokers were isolated by bronchoalveolar lavage and gene expression was measured. Chronic cigarette smoke exposure, as occurs in smoker's lungs, leads to significant changes in gene expression. Of note, RNA was isolated immediately following bronch...
ORGANISM(S): Homo sapiens 
2012-10-02 | E-GEOD-34517 | biostudies-arrayexpress
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