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MetabolomicsPomegranate Peel Extract as an Inhibitor of SARS-CoV-2 Spike Binding to Human ACE2 Receptor (in vitro): A Promising Source of Novel Antiviral Drugs
Plant extracts are rich in bioactive compounds, such as polyphenols, sesquiterpenes, and triterpenes, which potentially have antiviral activities. As a consequence of the coronavirus disease 2019 pandemic, caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) virus, thousands of...
2021-10-06 | MTBLS2309 | MetaboLights
ProteomicsHuman Angiotensin-Converting Enzyme 2-Specific Benzothiazole Allosteric Inhibitor against Pan-Sarbecoviruses
Emerging SARS-CoV-2 variants of concern (VOCs) have demonstrated exceptional transmissibility and a strong dependence on the cellular receptor human angiotensin-converting enzyme 2 (hACE2). In this study, we present MB-32, a benzothiazole-based small molecule allosteric inhibitor of hACE2, w...
ORGANISM(S): Homo sapiens (Human) Sarbecovirus 
2026-05-01 | PXD075140 | Pride
Human Mb-32 Entry inhibtor Angiotensin-converting enzyme 2 Covid19 Allosteric inhibitor Sarbecovirus Benzothiazole Formaldehyde crosslinking 
GenomicsPrevention of Events With Angiotensin-Converting Enzyme Inhibitor Therapy (PEACE_BioLINCC)
Prevention of Events With Angiotensin-Converting Enzyme Inhibitor Therapy (PEACE_BioLINCC)
PRJNA1431500 | ENA
GenomicsPrevention of Events With Angiotensin-Converting Enzyme Inhibitor Therapy (PEACE_BioLINCC)
Prevention of Events With Angiotensin-Converting Enzyme Inhibitor Therapy (PEACE_BioLINCC)
PRJNA1431498 | ENA
ProteomicsProteomic analysis of human macrophages overexpressing angiotensin-converting enzyme
Angiotensin converting enzyme (ACE) exerts strong modulation of myeloid cell function independently of its cardiovascular arm. The success of the ACE-overexpressing murine macrophage model, ACE 10/10, in treating microbial infections and cancer opens a new venture into whether ACE overexpression in ...
ORGANISM(S): Homo sapiens (Human) 
2025-06-09 | PXD052292 | Pride
Ace Swath Protein inhibitor Angiotensin Protein function 
ProteomicsSARS-Cov2 coronavirus spike protein-induced apoptosis, inflammatory and oxidative stress responses in THP-1-Like-Macrophages: potential role of angiotensin converting enzyme inhibitor (perindopril)
A purified spike (S) glycoprotein for SARS-COV-2 coronavirus was used to studying its effects on THP-1 macrophages, PBMCs and HUVEC cells. The S protein mediates SARS-CoV-2 entry into cells through binding to angiotensin converting enzyme 2 (ACE2) receptors. We measured viability, intracellular cyto...
ORGANISM(S): Severe acute respiratory syndrome coronavirus 2 Homo sapiens (Human) 
2021-11-16 | PXD025516 | Pride
Sars-cov-2 spike protein  monocyte/macrophages  inflammation  angiotensin converting enzyme inhibitor  proteomics 
TranscriptomicsEffect of Angiotensin Converting Enzyme Inhibitor or Angiotensin Receptor Blocker Exposure on Intragraft Gene Expression of Kidney Transplant Patients
Treatment with angiotensin converting enzyme inhibitors (ACEI) or angiotensin receptor blockers (ARB) has been shown to have anti-inflammatory effects such as decreased growth factors and cytokines in animal models, this effect however, has not been investigated in kidney transplant recipients. We ...
ORGANISM(S): Homo sapiens 
2016-06-10 | E-GEOD-83095 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of stroke-prone spontaneously hypertensive (SHRSP) rats treated with either an angiotensin II receptor (AT1R) antagonist or an angiotensin converting enzyme (ACE) inhibitor
Renin-angiotensin system (RAS) inhibition reduces stroke and improves brain capillary integrity in stroke prone spontaneously hypertensive rats (SHRSP). We tested the hypothesis that treatment with an angiotensin II receptor subtype 1 (AT1R) antagonist has different effects, compared to an angiotens...
ORGANISM(S): Rattus norvegicus 
2007-10-31 | E-GEOD-1548 | biostudies-arrayexpress
UnknownDipeptidyl peptidase IV in angiotensin-converting enzyme inhibitor associated angioedema.
Not available
S-EPMC2749928 | biostudies-literature
TranscriptomicsHippocampal gene expression profiling of a model of Alzheimer`s Disease upon treatment with the ACE inhibitor captopril
Extracellular senile plaques of amyloid beta (Abeta) are a pathological hallmark in brain of patients with Alzheimer`s Disease (AD). Abeta is generated by the amyloidogenic processing of the amyloid precursor protein (APP). Concomitant to Abeta load, AD brain is characterized by an increase in prote...
ORGANISM(S): Mus musculus 
2013-05-14 | E-GEOD-46871 | biostudies-arrayexpress
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