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MetabolomicsSarcosine decreases in sarcopenia and enhances muscle regeneration and adipose thermogenesis by activating ant-inflammatory macrophages (cohort2)

Age-related changes in circulating metabolites significantly influence systemic physiology and may contribute to diseases like sarcopenia. Although metabolic dysregulation is closely linked to sarcopenia, the roles of specific metabolites remain unclear. Here we performed comprehensive plasma met...

2025-05-06 | MTBLS12036 | MetaboLights
ProteomicsMouse Kidney MS - Standas diet WT/ High fat diet WT/ Standard diet ANT2 KO/ High fat diet ANT2 KO
Impairments in ATP production and transport in renal proximal tubule cells (RPTCs) result in obesity-induced chronic kidney disease (CKD), manifested by kidney dysfunction, inflammation, adiposity, and fibrosis. Here we assessed the role of adenine nucleotide transporter 2 (ANT2), the main regulator...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD042128 | Pride
Mouse Kidney Ms 
GenomicsANT2 accelerates cutaneous wound healing in aged skin by reverse senescence
ANT2 accelerates cutaneous wound healing in aged skin by reverse senescence
PRJNA849413 | ENA
TranscriptomicsANT2 accelerates cutaneous wound healing in aged skin by reverse senescence
An effective healing response is critical to healthy aging. Thus, the connection of regeneration and aging is needed to understand the complicated age-related healing process. Energy metabolism has been a common hallmark of both studies. In recent years, it become an emerging factor of skin homeosta...
ORGANISM(S): Homo sapiens 
2022-11-21 | GSE206141 | GEO
ProteomicsMetabolic Reprogramming Driven by Ant2 Deficiency Augments T Cell Function and Anti-Tumor Immunity
cell activation demands a significant boost in NAD+ levels, often outpacing the capacity of oxidative phosphorylation (OXPHOS). To explore how T cells manage this metabolic stress, we created T cell-specific ADP/ATP translocase-2 knockout (Ant2-/-) mice. Ant2, which is vital for ADP/ATP exchange bet...
ORGANISM(S): Mus musculus (Mouse) 
2025-04-09 | PXD062646 | Pride
Naive t cells Mouse Ant2ko Spleen 
UnknownMitochondrial Respiration-Dependent ANT2-UCP2 Interaction.
Not available
S-EPMC9177158 | biostudies-literature
UnknownANT2 drives proinflammatory macrophage activation in obesity.
Not available
S-EPMC8564915 | biostudies-literature
UnknownMitochondrial ATP transporter Ant2 depletion impairs erythropoiesis and B lymphopoiesis.
Not available
S-EPMC4532771 | biostudies-literature
GenomicsHomo sapiens
The function of ANT2
PRJDB38027 | ENA
UnknownKnockdown of Ant2 Reduces Adipocyte Hypoxia And Improves Insulin Resistance in Obesity.
Not available
S-EPMC6746433 | biostudies-literature
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