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Hereditary Leiomyomatosis and renal cell cancer (HLRCC) is caused by germline mutations of fumarate hydratase (FH) and subsequence accumulation of fumarate. Fumarate is known to activate the anti-oxidant response by KEAP1 succination and nuclear translocation of the transcription factor NRF2. The ac...
ORGANISM(S): Mus musculus (Mouse) 
2026-07-20 | PXD034141 | Pride
It is well appreciated that reactive oxygen species (ROS) are deleterious to mammals, including humans, especially when generated in abnormally large quantities from cellular metabolism. Whereas the mechanisms leading to the production of ROS are rather well delineated, the mechanisms underlying tis...
ORGANISM(S): Drosophila melanogaster 
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