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MetabolomicsWhole genome CRISPRi screening identifies druggable vulnerabilities in drug-resistant Mycobacterium tuberculosis

Tuberculosis (TB) remains a global health threat, aggravated by the emergence of drug-resistant strains. This study aims to identify genes and metabolic pathways with increased vulnerability in drug-resistant Mycobacterium tuberculosis strains compared to their drug-susceptible counterparts. Usin...

2024-10-15 | MTBLS11277 | MetaboLights
TranscriptomicsPain-killer carprofen elicits pleiotropic modes of bactericidal action with potential to reverse antimicrobial resistance in tuberculosis.
The alarming rise of antimicrobial resistance in Mycobacterium tuberculosis coupled with the shortage of new antibiotics has made tuberculosis (TB) control a global health priority. Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit the growth of multi-drug resistant isolates of M. tuberculosis....
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2020-08-15 | E-MTAB-6191 | biostudies-arrayexpress
UnknownDual-targeted anti-TB/anti-HIV heterodimers.
Not available
S-EPMC5576140 | biostudies-literature
UnknownThree enigmatic BioH isoenzymes are programmed in the early stage of mycobacterial biotin synthesis, an attractive anti-TB drug target.
Not available
S-EPMC9302846 | biostudies-literature
UnknownComprehensive physicochemical, pharmacokinetic and activity profiling of anti-TB agents.
Not available
S-EPMC7714050 | biostudies-literature
UnknownIn silico Design and Synthesis of Tetrahydropyrimidinones and Tetrahydropyrimidinethiones as Potential Thymidylate Kinase Inhibitors Exerting Anti-TB Activity Against Mycobacterium tuberculosis.
Not available
S-EPMC7082623 | biostudies-literature
UnknownAdvances in Key Drug Target Identification and New Drug Development for Tuberculosis.
Not available
S-EPMC8896939 | biostudies-literature
UnknownCurrent development and future prospects in chemotherapy of tuberculosis.
Not available
S-EPMC4461445 | biostudies-literature
TranscriptomicsPDE-4 inhibition alters gene expression and improves INH-mediated clearance of Mtb in rabbit lungs
Tuberculosis kills nearly 2 million people through out the world, every year. The outcome of M. tuberculosis infection is determined by the host and bacterial factors. A strong host immune response controls the growth of the bacilli effectively. However, in a host with suboptimal immune response,...
ORGANISM(S): Oryctolagus cuniculus 
2011-03-16 | E-GEOD-27992 | biostudies-arrayexpress
UnknownCytochrome P450 2E1 gene polymorphisms/haplotypes and anti-tuberculosis drug-induced hepatitis in a Chinese cohort.
Not available
S-EPMC3583841 | biostudies-literature
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