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MetabolomicsAntibacterial Monoclonal Antibodies Do Not Disrupt the Intestinal Microbiome or Its Function
Antibiotics revolutionized medicine, however, it is now clear that broad-spectrum antibiotics alter the composition and function of the host’s microbiome. The microbiome plays a key role in human health and its perturbation is increasingly recognized as contributing to many human diseases. Wide spre...
2021-01-11 | MTBLS1257 | MetaboLights
MetabolomicsUntargeted lipidomics of liver to assess the potential protective role in atherosclerosis progression of A12 antibodies infusion into LDLR-/-mice
Not available
ORGANISM(S): Mus musculus 
ST001434 | MetabolomicsWorkbench
TranscriptomicsExpression data from human NHL cell lines treated with agonistic antibodies
CD20 is a clinically validated target for Non-Hodgkin’s lymphomas and autoimmune diseases. Interactions of CD20 with the B cell receptor (BCR) and components of the BCR signaling cascade have been reported. In this study we show that antibodies against CD20 or activation of the BCR by specific antib...
ORGANISM(S): Homo sapiens 
2013-07-23 | E-GEOD-23394 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of endothelial cells and dermal fibroblasts treated with anti-HCMV antibodies to induce modifications typical of scleroderma phenotype
Both human endothelial cells and dermal fibroblasts have been treated with anti-HCMV antibodies to induce modifications typical of scleroderma phenotype.
ORGANISM(S): Homo sapiens 
2005-08-01 | E-MEXP-382 | biostudies-arrayexpress
ProteomicsEvaluation of phospho-tyrosine antibodies for label-free phosphoproteomics
In the past decade multiple tyrosine kinase inhibitors (TKIs) have been implemented in standard treatment regimens for patients with cancer. Unfortunately the majority of patients develops resistance to these drugs. Reliable tools for analysis of pharmacodynamic effects and drug resistance mechanism...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-10-21 | MSV000080270 | MassIVE
ModelsSumana2018 - Mathematical modeling of cancer-immune system, considering the role of antibodies.
Mathematical modeling of cancer-immune system, considering the role of antibodies. Ghosh S1, Banerjee S2. Author information 1 Department of Mathematics, Indian Institute of Technology Roorkee, Roorkee, Uttaranchal, 247667, India. 2 Department of Mathematics, Indian Institute of Technology ...
2024-09-02 | BIOMD0000000885 | BioModels
Immuno-oncology 
GenomicsChIP-seq validation of recombinant antibodies to histone post-translational modifications
Recombinant antibodies to histone post-translational modifications (PTMs), with their essentially infinite renewability, could fundamentally eliminate a major source of low reproducibility in epigenetics research. Here, we report new recombinant antibodies to trimethylated Lys4 and Lys9, respectivel...
ORGANISM(S): Homo sapiens 
2016-03-02 | E-GEOD-66530 | biostudies-arrayexpress
ProteomicsBaseline serum anti-glycan antibodies of 113 subjects in a clinical trial of PROSTVAC-VF, a therapeutic cancer vaccine [Validation IgG 1:50]
Purpose: There is evidence that therapeutic cancer vaccines can lengthen survival for some cancer patients, but responses vary widely from one person to another. Methods to predict clinical outcomes will advance the field and provide new insights into critical determinants of in vivo efficacy. Thi...
ORGANISM(S): Homo sapiens 
2013-04-01 | E-GEOD-42163 | biostudies-arrayexpress
ProteomicsBaseline serum anti-glycan antibodies of 28 subjects in a clinical trial of PROSTVAC-VF, a therapeutic cancer vaccine [Training IgG 1:50]
Purpose: There is evidence that therapeutic cancer vaccines can lengthen survival for some cancer patients, but responses vary widely from one person to another. Methods to predict clinical outcomes will advance the field and provide new insights into critical determinants of in vivo efficacy. Thi...
ORGANISM(S): Homo sapiens 
2013-04-01 | E-GEOD-42019 | biostudies-arrayexpress
Transcriptomics4-week mouse comparative study on effect of neutralizing IL-17A, IL-17F and TNFa antibodies
Molecular profiling of effect of TNFα neutralization in contrast to anti-IL-17A or anti-IL-17F treatment for 28 days in lungs of M. tuberculosis infected C57BL/6 mice. Animals were treated once per week (starting day-1) with anti-mouse IL-17A or IL-17F antibodies (20 mg/kg i.p.), anti-mouse TNFα a...
ORGANISM(S): Mus musculus 
2016-12-02 | E-MTAB-5218 | biostudies-arrayexpress
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