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MetabolomicsA conserved metabolic signature associated with response to fast-acting antimalarial agents

Characterizing the mode of action of antimalarial compounds that emerge from high-throughput phenotypic screens is central to understanding how parasite resistance to these drugs can emerge. Here, we have employed untargeted metabolomics to inform on the mechanism of action of antimalarial leads ...

2023-09-27 | MTBLS6580 | MetaboLights
Modelsvan-Heerden2023 - Chemical Features Identification for Stage-Specific Antimalarial Compounds
Prediction of the antimalarial potential of small molecules using data from various chemical libraries that were screened against the asexual and sexual (gametocyte) stages of the parasite. Several compounds’ molecular fingerprints were used to train machine learning models to recognize stage-specif...
2024-03-28 | MODEL2403270002 | BioModels
Machine Learning Model FAIR-AIML Ersilia 
TranscriptomicsEpigenetic marks reduce erythrocyte uptake of antimalarials
Acquired antimalarial drug resistance produces treatment failures and has led to periods of global disease resurgence. In P. falciparum, resistance is known to arise through genome-level changes such as mutations and gene duplications. We now report an epigenetic resistance mechanism involving genes...
ORGANISM(S): Plasmodium falciparum 
2013-06-03 | E-GEOD-47579 | biostudies-arrayexpress
GenomicsIdentification of antimalarial compounds that inhibit Apicomplexan AP2 transcription factor proteins in the human malaria parasite Plasmodium falciparum [ChIP-seq]
Plasmodium parasites are reliant on the Apicomplexan AP2 (ApiAP2) transcription factor family to regulate gene expression programs. AP2 DNA binding domains have no homologs in the human or mosquito host genomes, making them potential antimalarial drug targets. Using an in-silico screen to dock thous...
ORGANISM(S): Plasmodium falciparum 
2022-07-15 | GSE208155 | GEO
ProteomicsA novel antimalarial agent that inhibits protein synthesis in Plasmodium falciparum
Drug resistance to nearly all antimalarials following their rollout underscores the need for novel chemotypes with novel mode of action to replenish the antimalarial drug-development pipeline. We identified a novel class of compounds in the antimalarial armory. Compound 31, characterized by a hydrox...
ORGANISM(S): Plasmodium falciparum NF54 
2025-12-08 | PXD065399 | Pride
Drug discovery Drug resistance Hydroxy benzamides Antimalarial 
GenomicsIdentification of antimalarial compounds that inhibit Apicomplexan AP2 transcription factor proteins in the human malaria parasite Plasmodium falciparum
Identification of antimalarial compounds that inhibit Apicomplexan AP2 transcription factor proteins in the human malaria parasite Plasmodium falciparum
PRJNA837583 | ENA
UnknownAntimalarial properties and molecular docking analysis of compounds from Dioscorea bulbifera L. as new antimalarial agent candidates.
Not available
S-EPMC8132342 | biostudies-literature
UnknownIsolation and validation of antimalarial compounds from Phyllanthus emblica leaves for new antimalarial drug development.
Not available
S-EPMC12092577 | biostudies-literature
UnknownSynthesis of New Enantiopure Aminoalcohol Fluorenes as Promising Antimalarial Compounds.
Not available
S-EPMC11911300 | biostudies-literature
UnknownDiscovery of novel antimalarial compounds enabled by QSAR-based virtual screening.
Not available
S-EPMC3644566 | biostudies-literature
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