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MetabolomicsWe characterize the anti-phage function of a type IV TA system, ShosTA toxin-antitoxin system provides phage defense via DNA damage and repair
Widespread in bacteria and archaea, Toxin-antitoxin (TA) systems have been recently demonstrated to function in phage defense. Here we characterize the anti-phage function of a type IV TA system, ShosTA. Using structural and biochemical approaches, we show that ShosT couples phosphoribosyltransferas...
2025-02-17 | MTBLS11212 | MetaboLights
ProteomicsRetron Eco2 breaks tRNAs for antiphage defense
Retrons are prokaryotic reverse transcriptase systems that produce multicopy single-stranded DNA (msDNA), yet the principles by which they mediate antiviral defense remain largely unresolved. Here, we dissect the mechanism of Eco2, a minimal retron composed of a single reverse transcriptase–nuclease...
ORGANISM(S): Escherichia coli 
2026-02-23 | PXD067212 | Pride
Retron antiphage defense ribosomal protein s1 
GenomicsTranscriptomics reveals the role of NHEJ in mycobacterial antiphage defense
Transcriptomics reveals the role of NHEJ in mycobacterial antiphage defense
PRJNA1395048 | ENA
UnknownDisassembly activates Retron-Septu for antiphage defense.
Not available
S-EPMC12240667 | biostudies-literature
UnknownSerine recombinases are conserved genetic markers of antiphage defense systems.
Not available
S-EPMC12632615 | biostudies-literature
UnknownSystematic discovery of antiphage defense systems in the microbial pangenome.
Not available
S-EPMC6387622 | biostudies-literature
UnknownBacterial Hachiman complex executes DNA cleavage for antiphage defense.
Not available
S-EPMC11914072 | biostudies-literature
UnknownDesign of Specific Peptide Inhibitors of Toxin-Antitoxin-Mediated Antiphage Defense.
Not available
S-EPMC12739935 | biostudies-literature
UnknownResistance against aminoglycoside antibiotics via drug or target modification enables community-wide antiphage defense.
Not available
S-EPMC11350373 | biostudies-literature
UnknownDynamic control of bacterial antiphage defense through the CdnG-Cap5 cyclic oligonucleotide-based antiphage pathway in Vibrio cholerae.
Not available
S-EPMC12804361 | biostudies-literature
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