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MetabolomicsEx-Vivo Equine Cartilage Explant Osteoarthritis Model - A Metabolomics and Proteomics Study
Osteoarthritis (OA) is an age-related degenerative musculoskeletal disease characterised by loss of articular cartilage, synovitis, abnormal bone proliferation and subchondral bone sclerosis. Underlying OA pathogenesis is yet to be fully elucidated with no OA specific biomarkers in clinical use. Ex-...
2020-09-30 | MTBLS1495 | MetaboLights
TranscriptomicsComparison of steady state mRNA levels between equine articular cartilage and ten other equine tissues
A tissue survey of gene expression was conducted using microarray-based transcriptional profiling to compare equine articular cartilage to 10 other normal adult horse tissues. The ten comparative tissues were bladder, cerebellum, kidney, liver, lung, lymph node, muscle, placental villous, spleen, a...
ORGANISM(S): Equus caballus 
2011-01-27 | E-GEOD-23862 | biostudies-arrayexpress
TranscriptomicsExpression data from articular and growth plate cartilage
The aim of the current study was to identify molecular markers for articular cartilage that can be used for the quality control of tissue engineered cartilage. Therefore a genom-wide expression analysis was performed using RNA isolated from articular and growth plate cartilage, both extracted from t...
ORGANISM(S): Sus scrofa 
2011-07-28 | E-GEOD-23492 | biostudies-arrayexpress
MetabolomicsTargeting parkin-regulated metabolomic change in cartilage in the treatment of osteoarthritis
Articular cartilage degeneration, which may lead to osteoarthritis (OA), is a normal component of the aging process, but its underlying mechanism remains unknown. We found that chondrocytes exhibited an energy metabolism shift from glycolysis to oxidative phosphorylation (OXPHOS) during aging. Repro...
2024-07-17 | MTBLS9074 | MetaboLights
MetabolomicsTargeting parkin-regulated metabolomic change in cartilage in the treatment of osteoarthritis
Articular cartilage degeneration, which may lead to osteoarthritis (OA), is a normal component of the aging process, but its underlying mechanism remains unknown. We found that chondrocytes exhibited an energy metabolism shift from glycolysis to oxidative phosphorylation (OXPHOS) during aging. Repro...
2024-07-17 | MTBLS9079 | MetaboLights
TranscriptomicsSpatial Regulation of Gene Expression in Articular Cartilage Assessed by Laser Captured Microdissection and Microarray
We used laser capture microdissection to isolate different zones of the articular cartilage from proximal tibiae of 1-week old mice, and used microarray to analyze global gene expression. Bioinformatic analysis corroborated previously known signaling pathways, such as Wnt and Bmp signaling, and impl...
ORGANISM(S): Mus musculus 
2014-10-20 | E-GEOD-51994 | biostudies-arrayexpress
ProteomicsSexual Dimorphism in the Extracellular and Pericellular Matrix of Articular Cartilage
Male and female collagen-enriched fraction of cartilage from bovine knees. Full thickness cartilage plugs without subchondral bone were digested with chondroitinase for 24 hours to remove proteoglycans. Cartilage was further decellularized with SDS. LUM1_811145: channels 126, 127, 128 female, chan...
ORGANISM(S): Bos Taurus (ncbitaxon:9913) 
MSV000092997 | MassIVE
TranscriptomicsGene expression profiling of articular cartilage reveals functional pathways and networks of candidate genes for osteochondrosis in pigs
Osteochondrosis disorder is characterized by a failure of endochondral ossification of the articular-epiphyseal cartilage and the physeal growth cartilage. The number and identity of relevant genes are unknown. Simultaneously, 24,123 probe-sets were screened, of which 12,292 had present in at least ...
ORGANISM(S): Sus scrofa 
2013-10-21 | E-GEOD-44991 | biostudies-arrayexpress
ProteomicsUbiquitomics and proteomics analysis of porcine articular cartilage post mechanical injury
We describe ubiquitomics and proteomics analysis of porcine articular cartilage post mechanical injury. Analysis showed ubiquitin peptides differentially enriched post injury compared to non injured controls.
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2022-12-19 | PXD030817 | Pride
Injury Cartilage Ubiquitomics 
ProteomicsArticular cartilage proteome differentiates by zones during osteoarthritis
Articular cartilage is deprived of blood vessels and nerves, and the only cells residing in this tissue are chondrocytes. The molecular properties of the articular cartilage and the architecture of the extracellular matrix demonstrate a complex structure that differentiates on the depth of tissue. O...
ORGANISM(S): Homo sapiens (Human) 
2022-05-19 | PXD029116 | Pride
Osteoarthritis Zonal changes and ageing 
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