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MetabolomicsHigh-dose capsaicin exacerbates uveitis by disrupting intestinal ho-meostasis and upregulating IL-17
Purpose: To determine whether capsaicin (CAP) exacerbates experimental autoimmune uveitis (EAU) and whether this effect is associated with impaired intestinal homeostasis, gut microbiota re-modeling, and altered metabolic profiles. Methods: An EAU mouse model was used to evaluate the dose-dependent ...
2026-07-23 | MTBLS15144 | MetaboLights
Proteomicsequine CD4+ T cells show changed membrane protein expression in autoimmune uveitis
Through this comparative proteomic study of equine CD4+ cells 376 membrane proteins could be identified. Several proteins showed changed abundance in horses affected by a spontaneous autoimmune disease (equine recurrent uveitis, ERU). Findings provide novel knowledge about changes in the CD4+ immune...
ORGANISM(S): Equus caballus (Horse) 
2017-01-09 | PXD005384 | Pride
Lc-msms mass spectrometry analysis Membrane proteins Cd4+ t cells Autoimmune uveitis Equine recurrent uveitis 
ProteomicsProteome changes in retinal Mueller glial cells from a spontaneous equine model for autoimmune uveitis compared to healthy controls
Retinal Müller glial cells (RMG) play a central role in retinal neuroinflammation, actively participating in the immune response and adopting a dynamic inflammatory phenotype. However, the precise functions of RMG in retinal inflammation remain incompletely understood. In this study, we investigated...
ORGANISM(S): Equus caballus (Horse) 
2025-05-07 | PXD058170 | Pride
Quantitative label-free lc-ms/ms  retinal neuroinflammation  autoimmune uveitis  equine recurrent uveitis (eru)  spontaneous equine animal model  retinal mueller glial cells (rmg) 
ProteomicsProteome dynamcis in biobanked horse peripheral blood derived lymphocytes (PBL) with induced autoimmune uveitis
Equine recurrent uveitis (ERU) is the only spontaneous model for recurrent autoimmune uveitis in humans, where T cells target retinal proteins. Differences between normal and autoaggressive lymphocytes were identified in this study by analyzing peripheral blood derived lymphocytes (PBL) proteomes fr...
ORGANISM(S): Equus caballus (Horse) 
2017-08-31 | PXD005580 | Pride
Frozen Lc-msms Cfa Lymphocytes Inflammation Autoimmune 
TranscriptomicsEffector T cells driving monophasic vs relapse/remitting experimental autoimmune uveitis show unique pathway signatures
Experimental autoimmune uveitis (EAU) in Lewis rats is a model for the clinical heterogeneity of human uveitis. The autoantigens inducing disease in the rat are also seen in human disease. Depending upon the specific autoantigen used, the experimental disease course can be either monophasic or relap...
ORGANISM(S): Rattus norvegicus 
2010-12-01 | E-GEOD-19652 | biostudies-arrayexpress
GenomicsMurine CD4+ T cells: naive vs. experimental autoimmune uveitis
Murine CD4+ T cells: naive vs. experimental autoimmune uveitis
PRJNA878815 | ENA
GenomicsRetinal endothelial cell phenotypic modifications during experimental autoimmune uveitis: a transcriptomic approach
Retinal endothelial cell phenotypic modifications during experimental autoimmune uveitis: a transcriptomic approach
PRJNA602922 | ENA
GenomicsModulation of Immunosupressant Therapy by the Probiotic E. coli Nissle 1917 in Experimental Autoimmune Uveitis in Mice
Modulation of Immunosupressant Therapy by the Probiotic E. coli Nissle 1917 in Experimental Autoimmune Uveitis in Mice
PRJEB113260 | ENA
GenomicsSingle-cell transcriptomic analysis of retinal immune regulation and blood-retinal barrier function during experimental autoimmune uveitis
Single-cell transcriptomic analysis of retinal immune regulation and blood-retinal barrier function during experimental autoimmune uveitis
PRJNA1009136 | ENA
GenomicsHigh salt diet and uveitis
High salt diet and uveitis
PRJEB65938 | ENA
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