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TranscriptomicsThree Distinct Phases of Regeneration-Specific Gene Expression in the Axolotl Blastema
The salamander has the remarkable ability to regenerate its limb after amputation. Cells at the site of amputation form a blastema and then proliferate and differentiate to regrow the limb. To better understand this process, we have performed deep RNA sequencing of the blastema over a time course. W...
ORGANISM(S): Ambystoma mexicanum 
2013-09-01 | E-GEOD-34394 | biostudies-arrayexpress
TranscriptomicsDynamic membrane depolarization is an early regulator of ependymoglial cell response to spinal cord injury in axolotl
Salamanders, such as the Mexican axolotl, are some of the few vertebrates fortunate in their ability to regenerate diverse structures after injury. Unlike mammals they are able to regenerate a fully functional spinal cord after injury. However, the early signals required to initiate a pro-regenerati...
ORGANISM(S): Ambystoma mexicanum 
2016-07-05 | E-GEOD-71934 | biostudies-arrayexpress
TranscriptomicsSpatial transcriptomics of the axolotl forebrain
To investigate spatial heterogeneities in the axolotl forebrain, a coronal section of it was obtained for spatial transcriptomics using Visium V1.
ORGANISM(S): Ambystoma mexicanum 
2022-07-20 | E-MTAB-11665 | biostudies-arrayexpress
ProteomicsComparison of Protein Expression During Early Phases of Limb Regeneration Between Regeneration-permissive and Regeneration-deficient Axolotl
In this project, we studied the proteomic profiles of the early stages of blastema formation of neotenic and metamorphic axolotls after limb amputation by means of LC-MS/MS technology. We quantified a total of 714 proteins having an adjusted p < 0.01 with FC greater or equal to 2 between two conditi...
ORGANISM(S): Ambystoma mexicanum 
2019-11-25 | PXD014806 | Pride
Proteomics  axolotl  limb regeneration  metamorphosis  gene expression profile 
GenomicsSpatial transcriptomics of the axolotl forebrain
Spatial transcriptomics of the axolotl forebrain
PRJEB52491 | ENA
TranscriptomicsGenome-wide analysis reveals conserved transcriptional responses downstream of resting potential change in Xenopus embryos, axolotl regeneration, and human mesenchymal cell differentiation [axolotl data]
Endogenous bioelectric signaling via changes in cellular resting potential (Vmem) is a key regulator of patterning during regeneration and embryogenesis in numerous model systems. Depolarization of Vmem has been functionally implicated in de-differentiation, tumorigenesis, anatomical re-specificatio...
ORGANISM(S): Ambystoma mexicanum 
2016-07-03 | E-GEOD-72096 | biostudies-arrayexpress
TranscriptomicsExpression data from aquatic and terrestrial axolotl full thickness epithelial flank wounds collected over seven days
While considerable progress has been made towards understanding the complex processes and pathways that regulate human wound healing, regenerative medicine has been unable to develop therapies that coax the natural wound environment to heal scar-free. The inability to induce perfect skin regenerati...
ORGANISM(S): Ambystoma mexicanum 
2012-01-31 | E-GEOD-35255 | biostudies-arrayexpress
TranscriptomicsSmall RNA and mRNA expression profiling during axolotl forelimb regeneration
Previous studies of appendage regeneration in the axolotl have shown that multiple genetic programs are modulated through regulatory factors. MicroRNAs are short highly conserved non-coding genes that suppress expression of target genes and thereby control multiple genetic programs. Given their im...
ORGANISM(S): Ambystoma mexicanum 
2016-06-01 | E-GEOD-74372 | biostudies-arrayexpress
TranscriptomicsReprogramming to pluripotency is an ancient trait of vertebrate Oct4 and Pou2 proteins
The evolutionary origins of the gene network underlying cellular pluripotency, a central theme in developmental biology, have yet to be elucidated. In mammals, Oct4 is a factor crucial in the reprogramming of differentiated cells into induced pluripotent stem cells. The Oct4 and Pou2 genes evolved f...
ORGANISM(S): Homo sapiens 
2014-03-23 | E-GEOD-21302 | biostudies-arrayexpress
TranscriptomicsIdentification of conserved and novel microRNAs during tail regeneration in the Mexican Axolotl
The Mexican axolotl (Ambystoma mexicanum) is one member of a select group of vertebrate animals that has retained the amazing ability to regenerate multiple body parts. In addition to being an important model system for regeneration, the axolotl is also a leading model system for developmental biolo...
ORGANISM(S): Ambystoma mexicanum 
2015-09-11 | E-GEOD-72057 | biostudies-arrayexpress
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