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MetabolomicsHuman Gut Microbiota from Autism Spectrum Disorder Promote Behavioral Symptoms in Mice
Autism spectrum disorder (ASD) manifests as alterations in complex human behaviors including social communication and stereotypies. In addition to genetic risks, the gut microbiome differs between typically-developing (TD) and ASD individuals, though it remains unclear whether the microbiome contrib...
2019-07-04 | MTBLS726 | MetaboLights
ProteomicsEdaravone Promotes Adaptive Proteomic Remodeling and Improves Behavioral Outcomes in Chronic Heat Stress–Induced Brain Injury
Background: Heat stress is an increasing global health concern associated with high mortality and multi-organ dysfunction. The brain is particularly vulnerable, leading to behavioral impairments. At the molecular level, heat stress disrupts proteins involved in synaptic communication, mitochondrial ...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-06-16 | PXD079661 | Pride
Brain  heat stress  proteomics  edaravone  behavioral dysfunction. 
GenomicsImpairment of methylglyoxal detoxification systems causes mitochondrial dysfunction and behavioral deficits
Impairment of methylglyoxal detoxification systems causes mitochondrial dysfunction and behavioral deficits
PRJNA629318 | ENA
GenomicsLoss of neuronal 3D chromatin organization causes transcriptional and behavioral deficits related to serotonergic dysfunction [ChIP-seq]
The interior of the neuronal cell nucleus is a highly organized 3-dimensional (3D) structure in which regions of the genome that are millions of bases apart participate in specialized sub-structures with dedicated functions. To investigate neuronal chromatin organization and dynamics in vivo, we gen...
ORGANISM(S): Mus musculus 
2014-07-18 | E-GEOD-56809 | biostudies-arrayexpress
TranscriptomicsChanges in mouse cognition and hippocampal gene expression observed in a mild physical- and blast-traumatic brain injury
Warfare has long been associated with traumatic brain injury (TBI) in militarized zones. Common forms of TBI can be caused by a physical insult to the head-brain or by the effects of a high velocity blast shock wave generated by the detonation of an explosive device. While both forms of trauma are d...
ORGANISM(S): Mus musculus 
2013-03-18 | E-GEOD-44625 | biostudies-arrayexpress
TranscriptomicsLoss of neuronal 3D chromatin organization causes transcriptional and behavioral deficits related to serotonergic dysfunction
The interior of the eukaryotic cell nucleus is a highly organized 3D structure. In mature hippocampal and cortical pyramidal neurons, transcriptionally silent DNA is typically compacted in a few clusters referred to as chromocenters that are strongly stained with DNA intercalating agents like DAPI a...
ORGANISM(S): Mus musculus 
2014-07-18 | E-GEOD-48437 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of brains of adult honey bee workers (Apis mellifera) performing different behavioral tasks in the hive
This experiment examines gene expression profiles in the brains of adult honey bee workers (Apis mellifera) performing different behavioral tasks in the hive. The different behavioral groups examined were nurse, comb builder, guard, undertaker, and forager. The comb builder, guard, and undertaker be...
ORGANISM(S): Apis mellifera 
2005-01-21 | E-MEXP-252 | biostudies-arrayexpress
MetabolomicsCD22 Blockade Alleviates Anesthesia Surgery-Mediated Cognitive Impairment in Aged Mice

Postoperative cognitive dysfunction (POCD) is a common complication characterized by cognitive decline following surgery, with neuroinflammation serving as a critical pathogenic mechanism. Emerging evidence indicates that CD22, an inhibitory receptor primarily expressed on B cells and microglia, ...

2025-09-24 | MTBLS13028 | MetaboLights
ProteomicsProteomic and Behavioral Study of the Anxiolytic Effects of GABA in a Chronic Restraint Stress-Induced Anxiety Model
This study aimed to investigate the anxiolytic effects of GABA administration and its underlying molecular mechanisms in a chronic restraint stress (CRS)-induced anxiety model in C57BL/6J mice. CRS mice were established by placing the animals in well-ventilated 50 ml centrifuge tubes for 2 hours dai...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD059153 | Pride
Anxiety Gaba 
UnknownBehavioral sequelae of astrocyte dysfunction: focus on animal models of schizophrenia.
Not available
S-EPMC4439390 | biostudies-literature
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