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Proteomicsp38β-mediated BiP phosphorylation drives stemness and chemoresistance by suppressing UPR activation in hepatocellular carcinoma
Increasing evidence has demonstrated that tumor-initiating cells (TICs) contribute to tumor initiation and therapy resistance through dysregulation of kinase signaling. However, the intertwined networks of many kinases and their functional downstream targets are yet to be revealed and fully characte...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD067039 | Pride
Mapk11 Bip 
ProteomicsStructural basis of chaperone regulation by a post-translational modification
The Hsp70 chaperone BiP is covalently modified with adenosine monophosphate (referred to as AMPylation) in order to adapt its activity to the fluctuating folding load within the endoplasmic reticulum. This modification is catalyzed by the only human representative of the family of filamentation indu...
ORGANISM(S): Homo sapiens (Human) 
2021-04-27 | PXD022869 | Pride
Hype Ampylation Hsp70 chaperone bip 
ProteomicsCharacterisation of BiP-GRP94-HT2 interaction
Characterization of the interaction of BiP-GRP94 in the presence and absence of HT2 using cross linking with DSBU and subsequent analysis of cross linked peptides by LC-MS/MS
ORGANISM(S): Mus musculus (Mouse) 
2025-07-14 | PXD059917 | Pride
Bip  grp94  cross linking ms  cl-ms  dsbu 
ProteomicsCellular stress modulates severity of the inflammatory response in lungs via cell surface BiP
As BiP is involved in the ARDS mechanism of disease, we analyzed the proteomic profile of lung tissue challenged with LPS and/or treated with 4-PBA to identify pathways and components that link BiP and cellular stress with the hyperinflammatory response.
ORGANISM(S): Mus musculus (Mouse) 
2023-03-11 | PXD037978 | Pride
Lps Inflammation Bip Covid19 Cellular stress Grp78 
ProteomicsAtrogin-1 regulates BiP levels - novel therapeutic targets for Duchenne Muscular Dystrophy
Skeletal muscle wasting results from numerous pathological conditions impacting both the musculoskeletal and nervous systems. A unifying feature of these pathologies is the upregulation of members of the E3 ubiquitin ligase family, resulting in increased proteolytic degradation of target proteins. ...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2024-03-07 | PXD038406 | Pride
Atrogin-1  bip  duchenne muscular dystrophy zebrafish 
GenomicsTo study the mechanism of BIP regulation gene in 143B cells using RNA-seq Analysis
To study the mechanism of BIP regulation gene in 143B cells using RNA-seq Analysis
PRJNA798591 | ENA
ProteomicsA proximity labelling derived luminal proteome of the Trypanosoma brucei endoplasmic reticulum, Golgi apparatus and nuclear membrane
We employed proximity labelling to derive a proteome of the luminal content of the Trypanosoma brucei endoplasmic reticulum (ER) and Golgi apparatus. We exploited the abundant ER chaperone BiP (Binding-immunoglobulin protein) as ER BioID bait and compare to a truncated version of BiP (termed BiPN) d...
ORGANISM(S): Trypanosoma brucei 
2026-04-05 | PXD075517 | Pride
Nuclear envelope Secretory pathway Endoplasmic reticulum Golgi apparatus Trypanosoma brucei 
TranscriptomicsExpression data from Soybean leaves under drought stress and normally irrigated
BiP overexpression confers resistance to drought, through an as yet unknown mechanism that is related to ER functioning, has been described that the delay in leaf senescence by BiP overexpression might relate to the absence of the response to drought. We used microarrays to detail the global progra...
ORGANISM(S): Glycine max 
2013-08-29 | E-GEOD-50408 | biostudies-arrayexpress
TranscriptomicsBiP/GRP78 is a pro-viral factor for diverse dsDNA viruses that promotes the survival and proliferation of cells upon KSHV infection
The Endoplasmic Reticulum (ER)-resident HSP70 chaperone BiP (HSPA5) plays a crucial role in maintaining and restoring protein folding homeostasis in the ER. BiP’s function is often dysregulated in cancer and virus-infected cells, conferring pro-oncogenic and pro-viral advantages. We explored BiP's f...
ORGANISM(S): Homo sapiens 
2024-10-22 | GSE280006 | GEO
Genomics
BiP RNAi-induced differentially expressed genes
PRJNA1483951 | ENA
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