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ProteomicsHYPE mediated AMPylation profiling in human lysates
We describe here the first example of global chemoproteomic screening and substrate validation for HYPE mediated AMPylation in mammalian cell lysate. Through quantitative mass spectrometry-based proteomics coupled with novel chemoproteomic tools providing MS/MS evidence of AMP modification we identi...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080782 | MassIVE
ProteomicsHYPE mediated AMPylation profiling in human lysates
We describe here the first example of global chemoproteomic screening and substrate validation for HYPE mediated AMPylation in mammalian cell lysate. Through quantitative mass spectrometry-based proteomics coupled with novel chemoproteomic tools providing MS/MS evidence of AMP modification we identi...
ORGANISM(S): Homo sapiens (Human) 
2015-12-02 | PXD002601 | Pride
Hype Chemical proteomics Ampylation Fic 
ProteomicsHYPE mediated AMPylation site profiling with YnATP in human lysates
We describe here the first example of global chemoproteomic screening for HYPE mediated AMPylation sites of human proteins. Catalytically active mutant HYPE E234G was applied in combination with an alkynylated ATP and an alkynyl-biotinylated side ID reagent for capture of chemoenzymatically tagged ...
ORGANISM(S): Homo sapiens (Human) 
2015-12-02 | PXD003053 | Pride
Human Protein ampylation Chemoproteomics 
ProteomicsStructural basis of chaperone regulation by a post-translational modification
The Hsp70 chaperone BiP is covalently modified with adenosine monophosphate (referred to as AMPylation) in order to adapt its activity to the fluctuating folding load within the endoplasmic reticulum. This modification is catalyzed by the only human representative of the family of filamentation indu...
ORGANISM(S): Homo sapiens (Human) 
2021-04-27 | PXD022869 | Pride
Hype Ampylation Hsp70 chaperone bip 
ProteomicsProteomic and mutant analysis of hydrogenase gene hypE in symbiotic nitrogen fixation in Mesorhizobium huakuii
Hydrogenases catalyze the simple yet importantredox reaction between protons and electrons and H2, thus, mediate interactions between microorganisms and their chemical environment. A mutation in M. huakuii hypE gene was generated by homologous recombination. The hypE mutant grew a little faster than...
ORGANISM(S): Mesorhizobium huakuii 
2023-10-24 | PXD026564 | Pride
Mesorhizobium huakuii  fmoa  antioxidant  symbiotic nitrogen fixation  proteome & mesorhizobium huakuii  hydrogenases  hype gene  symbiotic nitrogen fixation  quantitative proteomics 
UnknownCrystal structure of the human, FIC-domain containing protein HYPE and implications for its functions.
Not available
S-EPMC4342408 | biostudies-literature
UnknownImplicit hype? Representations of platelet rich plasma in the news media.
Not available
S-EPMC5549909 | biostudies-literature
UnknownCrystal structures of the carbamoylated and cyanated forms of HypE for [NiFe] hydrogenase maturation.
Not available
S-EPMC3870729 | biostudies-literature
UnknownStructure of [NiFe] hydrogenase maturation protein HypE from Escherichia coli and its interaction with HypF.
Not available
S-EPMC2238214 | biostudies-literature
UnknownStructural basis for the reaction mechanism of S-carbamoylation of HypE by HypF in the maturation of [NiFe]-hydrogenases.
Not available
S-EPMC3436534 | biostudies-literature
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