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MetabolomicsInhibiting glutaminase exerts opposite effects on ovariectomy-induced and age-related reductions in murine bone mass
Recent studies have provided links between glutamine metabolism and bone remodeling, but little is known about its role in primary osteoporosis progression. We aimed to determine the effects of inhibiting glutaminase (GLS) on two types of primary osteoporosis and elucidate the related metabolism. To...
2024-06-17 | MTBLS9415 | MetaboLights
MetabolomicsPla2g7 regulates bone homeostasis via Alox12/12-HETE/Gpr31 signaling axis

Bone homeostasis mainly depends on the equilibrium of osteoclasts and osteoblasts, overactivated osteoclasts play a pivotal role in the progression of osteoporosis. Here, we revealed that Pla2g7 (phospholipase A2 group VII) was positively correlated with bone resorption in clinic. By single-cell ...

2025-10-30 | MTBLS13141 | MetaboLights
MetabolomicsUridine Attenuates Osteoclastogenesis and Ovariectomy Induced Bone Loss by Modulating the PI3K/Akt–FoxO ROS Signaling Axis

Osteoporosis is a metabolic bone disorder characterized by aberrant osteoclast activation, leading 

to excessive bone resorption and microarchitectural deterioration. Although the interconnection 

between osteoclast differentiation and cellular energy metabolism has been inc...

2026-04-09 | MTBLS13394 | MetaboLights
TranscriptomicsIdentification of differentially expressed genes between clinical and bovine-biased Escherichia coli O157:H7 genotypes
Escherichia coli O157:H7 strains have been classified into different genotypes based on the presence of specific shiga toxin-encoding bacteriophage insertion sites. Genotypes that are predominant in clinical isolates are named clinical genotypes and those that are isolated mostly from bovine source...
ORGANISM(S): Escherichia coli 
2010-06-19 | E-GEOD-15783 | biostudies-arrayexpress
ProteomicsExperimental maceration of bovine bones and its effects on the bone proteome
This study is aimed at understanding how bone soft maceration procedures (e.g., soaking the bones in warm water with the aid of detergents) used to process bones for long term storage (e.g., in human osteological collections) affect the bone proteome. Three different maceration protocols have been t...
ORGANISM(S): Bos taurus (Bovine) 
2023-03-08 | PXD032295 | Pride
Maceration Bone Shotgun proteomics 
TranscriptomicsRNA-Seq profiling of single bovine oocyte transcript abundance and its modulation by cytoplasmic polyadenylation
Polyadenylated RNA from individual germinal vesicle and metaphase II ooyctes was amplified and processed for Illumina sequencing. Increases in polyadenylated transcript abundance were observed and are likely due to cytoplasmic polyadenylation. Transcriptomic analysis of GV and MII bovine oocytes.
ORGANISM(S): Bos taurus 
2015-07-08 | E-GEOD-61717 | biostudies-arrayexpress
MetabolomicsComparative non-targeted LC-MS metabolomic profiling of murine bone marrow-derived macrophages cultured in 2D versus 3D

Macrophages are key drivers of inflammatory and fibrotic diseases and their activation is shaped by interactions in their tissue microenvironment. However, dissecting the processes that drive immunopathology has proved challenging as traditional 2D culture methods fail to capture the complex mole...

2026-06-08 | MTBLS12917 | MetaboLights
GenomicsGenome-Wide Landscapes of DNA Methylomes in Bovine Muscle Tissue
DNA methylation is a key epigenetic modification in mammals, have essential and important roles in muscle development. Here, using cattle as a model, we investigate the systematic association between DNA methylation and muscle development. We sample longissimus thoracis tissues from a famous elite n...
ORGANISM(S): Bos taurus 
2014-11-20 | E-GEOD-46504 | biostudies-arrayexpress
TranscriptomicsAn Atlas of Bovine Gene Expression Reveals Novel Distinctive Tissue Characteristics and Evidence for Improving Genome Annotation
Background: A comprehensive transcriptome survey, or "gene atlas", provides information essential for a complete understanding of the genomic biology of an organism. We present an atlas of RNA abundance for 92 adult, juvenile and fetal cattle tissues and 3 cattle cell lines. Results: The ...
ORGANISM(S): Bos taurus 
2010-09-28 | E-GEOD-21544 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of GR-N-91 neuroblasts injected subcutaneously into nude mice and a primary tumor Xenograft (PTX) was isolated whilst metastatic neuroblasts were isolated from Myocardium (MY) and Bone Marrow (BM)
We have used an IGR-N-91 parental cell line established from an involved bone marrow harvested from a high-risk NB (stage 4-NB, 8 year-old boy). These IGR-N-91 neuroblasts were injected subcutaneously into nude mice and a Primary Tumor Xenograft (PTX) was isolated whilst metastatic neuroblasts were...
ORGANISM(S): Homo sapiens 
2006-09-11 | E-TABM-44 | biostudies-arrayexpress
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