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ProteomicsA CPC-shelterin-BTR axis regulates mitotic telomere deprotection
Telomeres prevent ATM activation by sequestering chromosome termini within telomere loops (t-loops). Mitotic arrest promotes telomere linearity and a localized ATM-dependent telomere DNA damage response (DDR) through an unknown mechanism. Using unbiased interactomics, biochemical screening, molecula...
ORGANISM(S): Homo sapiens (Human) 
2025-01-28 | PXD043281 | Pride
Mitotic deprotection  cpc  shelterin  btr complex 
UnknownTelomere length heterogeneity in ALT cells is maintained by PML-dependent localization of the BTR complex to telomeres.
Not available
S-EPMC7197349 | biostudies-literature
UnknownCaenorhabditis elegans RMI2 functional homolog-2 (RMIF-2) and RMI1 (RMH-1) have both overlapping and distinct meiotic functions within the BTR complex.
Not available
S-EPMC8318279 | biostudies-literature
UnknownTranscription activation by the siderophore sensor Btr is mediated by ligand-dependent stimulation of promoter clearance.
Not available
S-EPMC3333878 | biostudies-literature
TranscriptomicsC. elegans nasp-1 / btr-1 mutant versus wild-type N2, exposed to pathogen Bacillus thuringiensis DB27
Transcriptional profiling of C. elegans nasp-1 / btr-1 mutant worms versus wild type N2 strain, both exposed to the bacterial pathogen Bacillus thuringiensis DB27. One-condition experiment. C. elegans nasp-1 / btr-1 mutant versus N2, exposed to Bacillus thuringiensis DB27. 3 biological replicates, i...
ORGANISM(S): Caenorhabditis elegans 
2013-01-31 | E-GEOD-43905 | biostudies-arrayexpress
UnknownA CPC-shelterin-BTR axis regulates mitotic telomere deprotection.
Not available
S-EPMC11914695 | biostudies-literature
UnknownImproved Genome Editing through Inhibition of FANCM and Members of the BTR Dissolvase Complex.
Not available
S-EPMC7934449 | biostudies-literature
UnknownMonopolar spindle 1 (MPS1) protein-dependent phosphorylation of RecQ-mediated genome instability protein 2 (RMI2) at serine 112 is essential for BLM-Topo III α-RMI1-RMI2 (BTR) protein complex function upon spindle assembly checkpoint (SAC) activation during mitosis.
Not available
S-EPMC3837099 | biostudies-literature
ProteomicsThe Bloom Syndrome Complex Senses RPA-Coated Single-Stranded DNA to Restart Stalled Replication Forks
The Bloom syndrome helicase BLM interacts with topoisomerase IIIa (TOP3A), RMI1 and RMI2 to form the BTR complex, which dissolves double Holliday junctions to produce non-crossover products during homologous recombination (HR). BLM also promotes DNA-end resection and stalled replication fork restart...
ORGANISM(S): Homo sapiens (Human) 
2021-01-05 | PXD018322 | Pride
Bloom syndrome Dna damage response Blm Rpa Homologous recombination Replication stress 
UnknownThe topoisomerase 3 zinc finger domain cooperates with the RMI1 scaffold to promote stable association of the BTR complex to recombination intermediates in the Caenorhabditis elegans germline.
Not available
S-EPMC9178014 | biostudies-literature
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