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TranscriptomicsTranscription profiling of mouse embryonic day 13.5 and 15.5 fetal livers lacking p38alpha, a mitogen-activated kinase that controls inflammatory responses and cell proliferation
The mitogen-activated protein kinase (MAPK) p38alpha controls inflammatory responses and cell proliferation. Using mice carrying conditional p38alpha alleles, we investigated its function in postnatal development and tumorigenesis. When p38alpha is specifically deleted in the mouse embryo, fetuses d...
ORGANISM(S): Mus musculus 
2007-12-13 | E-GEOD-7342 | biostudies-arrayexpress
Proteomicsc-JUN interacte with NuRD complex to regulate chromatin remodeling
detect c-JUN interaction proteins in humanembryonic stem cells
ORGANISM(S): Homo Sapiens 
2023-12-28 | PXD048153 |
TranscriptomicsCHIP Analysis - c-Jun/ATF2
Identification of promoters bound by c-Jun/ATF2 during rapid large-scale gene activation following genotoxic stress
ORGANISM(S): Homo sapiens 
2010-06-05 | E-GEOD-1810 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat aortic smooth muscle cells transfected with dominant negative or upregulated JNK1 and subjected to oxidative stress
Oxidative stress-dependent genes are defined as those induced or suppressed by H2O2 treatement in rat vascular smooth muscle cells. JNK-induced genes in rat vascular smooth muscle cells are defined as those induced by adenoviruses encoding constitutively active MKK7 (caMKK7) + wild type JNK1 (wtJNK1...
ORGANISM(S): Rattus norvegicus 
2007-10-08 | E-GEOD-2190 | biostudies-arrayexpress
TranscriptomicsInterplay between c-Jun and TAp73M-NM-1/M-NM-2 contributes to the apoptosis-survival balance
The p53-family member p73 functions in various cellular signaling pathways and can have tumor suppressor properties. Several isoforms of p73 exist that differ considerably in their function. Whereas the functions of the N-terminal isoforms (TA and M-NM-^TNp73) and their opposing pro- and anti-apopto...
ORGANISM(S): Homo sapiens 
2011-03-01 | E-GEOD-15780 | biostudies-arrayexpress
TranscriptomicsDifferential Regulation of Mitogen-Activated Protein Kinases by Acetaminophen in TAMH cells
Acetaminophen (APAP), a widely used analgesic and antipyretic that is considered to be relatively safe at recommended doses, is the leading cause of drug-induced liver failure in the United States. 3M-bM-^@M-^Y-Hydroxyacetanilide (AMAP), a regioisomer of acetaminophen is useful as a comparative too...
ORGANISM(S): Mus musculus 
2010-07-06 | E-GEOD-18614 | biostudies-arrayexpress
TranscriptomicsFailures of nerve regeneration caused by aging or chronic denervation are rescued by restoring Schwann cell c-Jun
After nerve injury, myelin and Remak Schwann cells reprogram to repair cells specialized for regeneration. Normally providing strong regenerative support, these cells fail in aging animals, and during the chronic denervation that results from slow axon growth. This impairs axonal regeneration and ca...
ORGANISM(S): Mus musculus 
2020-10-14 | E-MTAB-9640 | biostudies-arrayexpress
GenomicsOverlapping role of c-Jun N-terminal kinase (JNK) 1 and 2 in imidazole ketone erastin-induced ferroptosis
Overlapping role of c-Jun N-terminal kinase (JNK) 1 and 2 in imidazole ketone erastin-induced ferroptosis
PRJNA983694 | ENA
TranscriptomicsA chromatin-modifying function of JNK during stem cell differentiation
Signaling mediates cellular responses to extracellular stimuli. The c-Jun NH2-terminal kinase (JNK) pathway exemplifies one sub-group of Mitogen-activated protein (MAP) kinases, which besides established functions in stress response, also contributes to developmental processes by an unknown mechanis...
ORGANISM(S): Mus musculus 
2011-12-18 | E-GEOD-25532 | biostudies-arrayexpress
TranscriptomicsJnk1 in murine hepatic stellate cells is a crucial mediator of liver fibrogenesis
Hepatic fibrosis is a wound-healing response to chronic liver injury, which may result in cirrhosis and liver failure. The c-Jun N-terminal kinase-1 (JNK1) gene has been shown to be involved in liver fibrosis. Here, we aimed to investigate the molecular mechanism and identify the cell-type involved ...
ORGANISM(S): Mus musculus 
2013-11-27 | E-GEOD-40041 | biostudies-arrayexpress
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