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ProteomicsIdentification of C2CD4A and C2CD4B binding partners in MIN6 cells
Variants close to the VPS13C/C2CD4A/C2CD4B locus are associated with altered risk of type 2 diabetes in genome-wide association studies. Whilst previous functional work has suggested roles for VPS13C and C2CD4A in disease development, none has explored the role of C2CD4B. Here, we show that systemic...
ORGANISM(S): Mus musculus (Mouse) 
2020-11-16 | PXD021597 | Pride
C2cd4a  c2cd4b  interaction proteomics 
GenomicsSexually dimorphic roles for the type 2 diabetes-associated C2cd4b gene in murine glucose homeostasis
Sexually dimorphic roles for the type 2 diabetes-associated C2cd4b gene in murine glucose homeostasis
PRJNA639774 | ENA
TranscriptomicsSexually dimorphic roles for the type 2 diabetes-associated C2cd4b gene in murine glucose homeostasis
Variants close to the VPS13C/C2CD4A/C2CD4B locus are associated with altered risk of type 2 diabetes in genome-wide association studies. Here have performed RNAseq on pancreatic islets from C2CD4B-null mice and their littermate controls.
ORGANISM(S): Mus musculus 
2020-09-16 | GSE152576 | GEO
UnknownC2CD4B Evokes Oxidative Stress and Vascular Dysfunction via a PI3K/Akt/PKCα-Signaling Pathway.
Not available
S-EPMC10812653 | biostudies-literature
UnknownSexually dimorphic roles for the type 2 diabetes-associated C2cd4b gene in murine glucose homeostasis.
Not available
S-EPMC7829492 | biostudies-literature
UnknownA Common Type 2 Diabetes Risk Variant Potentiates Activity of an Evolutionarily Conserved Islet Stretch Enhancer and Increases C2CD4A and C2CD4B Expression.
Not available
S-EPMC5985342 | biostudies-literature
UnknownSelective Transcription Factor Blockade Reduces Human Retinal Endothelial Cell Expression of Intercellular Adhesion Molecule-1 and Leukocyte Binding.
Not available
S-EPMC9967456 | biostudies-literature
UnknownVariants in GLIS3 and CRY2 are associated with type 2 diabetes and impaired fasting glucose in Chinese Hans.
Not available
S-EPMC3126830 | biostudies-literature
UnknownGenetic variation at glucose and insulin trait loci and response to glucose-insulin-potassium (GIK) therapy: the IMMEDIATE trial.
Not available
S-EPMC6512969 | biostudies-literature
UnknownIdentification of C2CD4A as a human diabetes susceptibility gene with a role in β cell insulin secretion.
Not available
S-EPMC6778232 | biostudies-literature
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