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MetabolomicsTobacco-specific carcinogens in Bladder Cancer
Not available
ORGANISM(S): Homo sapiens 
ST000614 | MetabolomicsWorkbench
TranscriptomicsDissecting modes of action of non-genotoxic carcinogens in primary mouse hepatocytes.
Under REACH, the European Community Regulation on chemicals, the testing strategy for carcinogenicity is generally based on in vitro and in vivo genotoxicity assays. Given that non-genotoxic carcinogens are negative for genotoxicity, this class of carcinogens will not be detected. Therefore, alterna...
ORGANISM(S): Mus musculus 
2012-06-25 | E-GEOD-35058 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of the effect of chemical mutagens and carcinogens on gene expression profiles in human TK6 cells
Direct and indirect- acting genotoxic carcinogens at 3 dose levels i.e., low, medium and high with and without S9 metabolic mix, were exposed to TK6 cells along with control TK6 cell cultures in- vitro. Total RNA was isolated and hybridized to illumina microarrays to assess the effects of carcinoge...
ORGANISM(S): Homo sapiens 
2012-06-04 | E-TABM-1223 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of primary mouse hepatocytes reveals classification for genotoxic and non-genotoxic carcinogens by gene expression improves with exposure time
The prediction of possible carcinogenicity of chemicals for humans represents an ongoing challenge. Chronic rodent bioassays predict human cancer risk at only limited reliability while simultaneously being expensive and long-lasting. In order to seek for alternatives, in the present study, the abil...
ORGANISM(S): Mus musculus 
2010-06-09 | E-MEXP-2209 | biostudies-arrayexpress
TranscriptomicsGene expression profiling to recognize specific features of non-genotoxic carcinogens
The current test strategy for carcinogenicity is generally based on in vitro and in vivo genotoxicity assays. Non-genotoxic carcinogens (NGTXC) are negative for genotoxicity and go undetected. Therefore, alternative tests to detect these chemicals are urgently needed. NGTXC act through different mod...
ORGANISM(S): Mus musculus 
2014-10-23 | E-GEOD-44088 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mice liver after treatment for 2 weeks with different known carcinogens and non-carcinogens
Previously we demonstrated that the mouse liver tumor response to the non-genotoxic carcinogens oxazepam [CAS:604-75-1;CHEBI:7823] and Wyeth-14,643 [CAS:50892-23-4;CHEBI:32509] involved more differences than similarities in changes in early gene expression. In this study we used quantitative real-ti...
ORGANISM(S): Mus musculus 
2007-01-10 | E-TOXM-18 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human hepatoma cell lines HepG2 and HepaRG using whole genome gene expression analysis before and after exposure to the GTX carcinogens AFB1 and BaP, and the NGTX carcinogens CsA, E2 and TCDD for 12 and 48 h
Direct comparison of the hepatoma cell lines HepG2 and HepaRG using whole genome gene expression analysis before and after exposure to the GTX carcinogens AFB1 and BaP and the NGTX carcinogens CsA, E2 and TCDD for 12 and 48 h.
ORGANISM(S): Homo sapiens 
2010-04-15 | E-MEXP-2458 | biostudies-arrayexpress
UnknownAn integrated in vitro carcinogenicity test that distinguishes between genotoxic carcinogens, non-genotoxic carcinogens, and non-carcinogens.
Not available
S-EPMC10928837 | biostudies-literature
TranscriptomicsDissecting modes of action of non-genotoxic carcinogens in primary mouse hepatocytes.
Under REACH, the European Community Regulation on chemicals, the testing strategy for carcinogenicity is generally based on in vitro and in vivo genotoxicity assays. Given that non-genotoxic carcinogens are negative for genotoxicity, this class of carcinogens will not be detected. Therefore, alterna...
ORGANISM(S): Mus musculus 
2012-06-26 | GSE35058 | GEO
GenomicsGene expression and epigenetic alterations in human hepatocytes treated with low doses of chemical carcinogens
Gene expression and epigenetic alterations in human hepatocytes treated with low doses of chemical carcinogens
PRJNA525409 | ENA
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