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TranscriptomicsGene expression profile in Caco-2 cells treated with carnosine
To reveal the effects of carnosine on Caco-2 cells, we have employed whole genome microarray to detect genes that showed significantly different expression when exposed to carnosine. Caco-2 cells were treated with 1 mM carnosine for 3 days. Caco-2 cells were treated with 1 mM carnosine for 3 days. T...
ORGANISM(S): Homo sapiens 
2015-03-31 | E-GEOD-61455 | biostudies-arrayexpress
ProteomicsCarnosine effect in scaffold free human dermis spheroids model
Carnosine is an endogenous β-alanyl-L-histidine dipeptide endowed of antioxidant and carbonyl scavenger properties, able to significantly prevent the visible signs of aging and photoaging. To deeply investigate the mechanism of action of carnosine on human skin proteome, a 3D scaf-fold-free spheroid...
ORGANISM(S): Homo sapiens (Human) 
2022-02-22 | PXD031053 | Pride
Carnosine Spheroids Label free 
ProteomicsA phosphoproteomic and transcriptomic analysis of carnosine’s action on signaling in glioblastoma U87-MG cells
Previous studies demonstrated that carnosine affects signaling molecules of different pathways in a number of experimental models. However, the primary targets of carnosine are still unknown and its effect on complex signal transduction has not been revealed. This is especially the case for pathways...
ORGANISM(S): Homo sapiens 
2019-11-30 | E-MTAB-6455 | biostudies-arrayexpress
ProteomicsThe Carnosine–HNE Michael Adduct as a Redox-Active Species Associated with Nrf2-Dependent Antioxidant and An-ti-Inflammatory Responses
Carnosine (CAR), an endogenous histidine-containing dipeptide, exhibits antioxidant and anti-inflammatory activity in various experimental models; however, its molecular mechanism of action remains poorly understood. Here, we demonstrate that the Michael adduct between CAR and 4-hydroxy-2-nonenal (H...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-06 | PXD075159 | Pride
Carnosine  4-hydroxy-2-nonenal (hne)  nrf2 activation  nf-κb  anti-inflammatory  anti-oxidant. 
TranscriptomicsGene expression profile in Caco-2 cells treated with carnosine
To reveal the effects of carnosine on Caco-2 cells, we have employed whole genome microarray to detect genes that showed significantly different expression when exposed to carnosine. Caco-2 cells were treated with 1 mM carnosine for 3 days.
ORGANISM(S): Homo sapiens 
2015-03-31 | GSE61455 | GEO
GenomicsRNA-Sequencing of carnosine treated wild-type BDF1 (WT) and transgenic Thy1-aSyn mice
RNA-Sequencing of carnosine treated wild-type BDF1 (WT) and transgenic Thy1-aSyn mice
PRJNA475977 | ENA
TranscriptomicsRNA-Sequencing of carnosine treated wild-type BDF1 (WT) and transgenic Thy1-aSyn mice
Mitochondrial dysfunction plays a central role in the pathogenesis of neurodegenerative diseases such as Parkinson’s disease (PD). This study tested the hypothesis that the dipeptide carnosine would exert a beneficial effect in the Thy1-aSyn mouse model of PD, which displays mitochondrial dysfunctio...
ORGANISM(S): Mus musculus 
2018-12-31 | GSE115769 | GEO
TranscriptomicsIron scavenging and suppression of collagen cross-linking underlie antifibrotic effects of carnosine in the heart with obesity
Oral consumption of histidyl dipeptides such as l-carnosine has been suggested to promote cardiometabolic health, although therapeutic mechanisms remain incompletely understood. We recently reported that oral consumption of a carnosine analog suppressed markers of fibrosis in liver of obese mice, bu...
ORGANISM(S): Mus musculus 
2023-12-19 | GSE250315 | GEO
GenomicsRNA sequencing of LT-HSCs from the bone marrow of unirradiated mice after treated with saline or carnosine
RNA sequencing of LT-HSCs from the bone marrow of unirradiated mice after treated with saline or carnosine
PRJNA1181876 | ENA
TranscriptomicsRNA Profiles of the Korat Chicken Breast Muscle with Increased Carnosine Content Produced through Dietary Supplementation with β-Alanine or L-Histidine
Carnosine is a bioactive food component with several potential health benefits for humans due to its physiological functions. Dietary　supplementation with β-alanine or L-histidine can increase the carnosine content of skeletal muscles in chickens. Dietary supplementation with β-alanine or L-histidin...
ORGANISM(S): Gallus gallus 
2021-09-04 | GSE179643 | GEO
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