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TranscriptomicsThe role of Raf-1 kinase inhibitor protein in the regulation of pancreatic beta cell proliferation in mice
AIMS/HYPOTHESIS: Manoeuvres aimed at increasing beta cell mass have been proposed as regenerative medicine strategies for diabetes treatment. Raf-1 kinase inhibitor protein 1 (RKIP1) is a common regulatory node of the mitogen-activated protein kinase (MAPK) and nuclear factor κB (NF-κB) pathways and...
ORGANISM(S): Mus musculus 
2012-11-19 | E-GEOD-31150 | biostudies-arrayexpress
TranscriptomicsAT13148 is a novel, oral multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity
Purpose: Deregulated phosphatidylinositol 3-kinase pathway signaling through AGC kinases including AKT, p70S6 kinase, PKA, SGK and Rho kinase, is a key driver of multiple cancers. The simultaneous inhibition of multiple AGC kinases may increase antitumor activity and minimize clinical resistance com...
ORGANISM(S): Homo sapiens 
2012-07-19 | E-GEOD-38008 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human peripheral blood mononuclear cells treated with a CDK inhibitor
A genomics-based approach to identify pharmacodynamic biomarkers was used for a CDK (cyclin-dependent kinase) inhibitory drug. R547 is a potent CDK inhibitor with a potent anti-proliferative effect at pharmacologically relevant doses, and is currently in Phase I clinical trials. Utilizing preclinic...
ORGANISM(S): Homo sapiens 
2009-03-28 | E-GEOD-15389 | biostudies-arrayexpress
TranscriptomicsTranscriptional analysis of an E2F gene signature as a biomarker of activity of the cyclin-dependent kinase inhibitor PHA-793887 in tumor and skin biopsies from a phase I clinical study
Microarray analysis of transcriptional changes in biopsies of solid tumors from patients treated in a Phase I study with the Cdk inhibitor PHA-793887. 7 patient biopsies pre- and post-treatment in dye swap. Tumors are of different origins, and are described in the accompanying manuscript.
ORGANISM(S): Homo sapiens 
2010-05-28 | E-GEOD-18553 | biostudies-arrayexpress
UnknownResearch towards selective inhibition of the CLK3 kinase.
Not available
S-EPMC12557437 | biostudies-literature
ProteomicsChemical phosphoproteomics reveals kinase network topologies associated to genotypes and phenotypes of cancer cells.
We compare the in vitro specificity profiles of several kinase inhibitors with their effects on cellular phosphoproteomes. For this aim, we developed an algorithm which utilizes information on kinase inhibitor selectivity to determine the most probable kinase(s) acting upstream of phosphorylation si...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-10-22 | MSV000090571 | MassIVE
TranscriptomicsFGFR signature
Drugs that target specific gene alterations have proven beneficial in the treatment of cancer. Because cancer cells have multiple resistance mechanisms, it is important to understand the downstream pathways of the target genes and monitor the pharmacodynamic markers associated with therapeutic effic...
ORGANISM(S): Homo sapiens 
2016-01-06 | E-GEOD-73024 | biostudies-arrayexpress
UnknownPharmacophore and 3D-QSAR characterization of 6-arylquinazolin-4-amines as Cdc2-like kinase 4 (Clk4) and dual specificity tyrosine-phosphorylation-regulated kinase 1A (Dyrk1A) inhibitors.
Not available
S-EPMC3633254 | biostudies-literature
UnknownCDC2-like (CLK) protein kinase inhibition as a novel targeted therapeutic strategy in prostate cancer.
Not available
S-EPMC8041776 | biostudies-literature
ProteomicsIdentifications of protein kinase A substrates with quantitative phosphoproteomics and primary-sequence based scoring.(H-89)
Protein kinase A (PKA) is a serine/threonine kinase who plays essential roles in the complex signalling pathways. To better understand the functionalities, it is necessary to elucidate direct interplays between PKA and their substrates in living system. In order to screen them in a high-throughput m...
ORGANISM(S): Homo Sapiens (human) 
2018-02-15 | PXD005925 | JPOST Repository
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