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MetabolomicsFruit setting rewires central metabolism via gibberellin cascades
Fruit set is the process whereby ovaries develop into fruits after pollination and fertilization. The process is induced by the phytohormone gibberellin (GA) in tomatoes, as determined by the constitutive GA response mutant procera However, the role of GA on the metabolic behavior in fruit-setting o...
2020-09-11 | MTBLS1892 | MetaboLights
TranscriptomicsIdentification of central nervous system genes involved in the host response to the scrapie agent.
In this study we identified genes differentially expressed in the central nervous system (CNS) of mice during infection with mouse-adapted scrapie agents. We used cDNA microarrays to examine gene expression profiles at early, mid (pre-clinical) and late (clinical) time points after inoculation. Keyw...
ORGANISM(S): Mus musculus 
2004-10-13 | E-GEOD-1840 | biostudies-arrayexpress
ProteomicsSkeletal Muscle TFEB Signaling Promotes Central Nervous System Function and Reduces Neuroinflammation during Aging and Neurodegenerative Disease
Skeletal muscle has recently arisen as a novel regulator of Central Nervous System (CNS) function and aging, secreting bioactive molecules known as myokines with metabolism-modifying functions in targeted tissues, including the CNS. Here we report the generation of a novel transgenic mouse with enha...
ORGANISM(S): Mus Musculus 
2023-12-06 | PXD045241 | panorama
TranscriptomicscaArray_golub-00460: Prediction of central nervous system embryonal tumour outcome based on gene expression
Embryonal tumours of the central nervous system (CNS) represent a heterogeneous group of tumours about which little is known biologically, and whose diagnosis, on the basis of morphologic appearance alone, is controversial. Medulloblastomas, for example, are the most common malignant brain tumour of...
ORGANISM(S): Homo sapiens 
2015-05-16 | E-GEOD-68956 | biostudies-arrayexpress
TranscriptomicsGenomic aberrations in primary central nervous system lymphoma (PCNSL)
Genomic aberrations in primary central nervous system lymphoma (PCNSL). Two-condition experiment, PCNSLs vs. healthy men. Biological replicates: 12 tumors replicates, 13 peripheral blood replicates.
ORGANISM(S): Homo sapiens 
2010-11-13 | E-GEOD-25298 | biostudies-arrayexpress
ProteomicsPhosphoproteome Analysis of Cerebrospinal Fluid Extracellular Vesicles in Primary Central Nervous System Lymphoma
Primary central nervous system lymphoma(PCNSL) is a rare extra-nodal non-Hodgkin’s lymphoma and accounts for 3%-4% of central nervous system tumors. Recent studies have highlighted the importance of cerebrospinal fluid derived extracellular vesicles in PCNSL. Extracellular vesicles(EVs) are nanoscal...
ORGANISM(S): Homo Sapiens (human) 
2023-07-12 | PXD040744 | JPOST Repository
TranscriptomicsGenomic profiling combined with gene expression profiling in primary central nervous system lymphoma
This SuperSeries is composed of the following subset Series: GSE25297: Genome-wide gene expression comparison (primary central nervous system lymphoma (PCNSL) vs normal lymph node) GSE25298: Genomic aberrations in primary central nervous system lymphoma (PCNSL) Refer to individual Series
ORGANISM(S): Homo sapiens 
2010-11-13 | E-GEOD-25299 | biostudies-arrayexpress
TranscriptomicsRNA-sequencing reveals oligodendrocyte and neuronal transcripts in microglia relevant to central nervous system disease
Expression profiling of distinct central nervous system (CNS) cell populations has been employed to facilitate disease classification and to provide insights into the molecular basis of brain pathology. One important cell type implicated in a wide variety of CNS disease states is the resident brain ...
ORGANISM(S): Mus musculus 
2015-01-30 | E-GEOD-53789 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse spinal cord and dorsal root ganglion to test the fundamental quantitative differences between central and peripheral nervous system transcriptomes
We used microarrays to test the fundamental quantitative differences between central and peripheral nervous system transcriptomes. Experiment Overall Design: 3 independent SC and 3 independent DRG samples were analyzed. Each sample contained material from 4 age-matched male C57B/6 mice.
ORGANISM(S): Mus musculus 
2007-11-27 | E-GEOD-5425 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human primary lymphomas of the central nervous system suggests PCNSL to be derived from a late germinal center B cell.
To characterize the molecular origin of primary lymphomas of the central nervous system (PCNSL), 21 PCNSL of immunocompetent patients were investigated by microarray-based gene expression profiling. Comparison of the transcriptional profile of PCNSL with various normal and neoplastic B cell subsets ...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6047 | biostudies-arrayexpress
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