cerebral ischemia and reperfusion

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Global transcriptomic profiling of ischemic/reperfusion injury in an in vivo wild-type mouse model.

Ischemic stroke triggers severe focal hypoperfusion accompanied with deprivation of oxygen and glucose to the cerebral tissue, together with loss of ATP, depolorization of neurons, elevated extracellular potassium concentration, and subsequently leads to excitotoxicity as well as increased oxidative...

ORGANISM(S): Mus musculus

2011-01-10 | E-GEOD-23160 | biostudies-arrayexpress

Global transcriptomic profiling of ischemic/reperfusion injury in an in vivo mouse model.

This SuperSeries is composed of the following subset Series: GSE23160: Global transcriptomic profiling of ischemic/reperfusion injury in an in vivo wild-type mouse model. GSE23162: Global transcriptomic profiling of ischemic/reperfusion injury in an in vivo Gpx1 -/- transgenic mouse model. Refer to ...

ORGANISM(S): Mus musculus

2011-01-10 | E-GEOD-23163 | biostudies-arrayexpress

Global transcriptomic profiling of ischemic/reperfusion injury in an in vivo Gpx1 -/- transgenic mouse model.

Glutathione peroxidase (Gpx) is a selenium-containing enzyme that catalyses the reduction of a variety of biological peroxides at the expense of reduced glutathione (GSH). Gpx1 is the most abundant isoform and its role has been implicated in neurodegenerative disorders such as ParkinsonM-bM-^@M-^Ys ...

ORGANISM(S): Mus musculus

2011-01-10 | E-GEOD-23162 | biostudies-arrayexpress

phosphoproteome of hippocampus after focal cerebral ischemia 1.5 h and reperfusion 24 h in mice

We obtained the profiles of neuronal phosphoproteome after cerebral ischemia and reperfusion by isolating mice hippocampus. Hippocampus combined from either nine sham or nine focal cerebral ischemia 1.5 h and reperfusion 24 h (IR) mice were lysed, digested, labeled with different TMT tags, then pool...

ORGANISM(S): Mus musculus (Mouse)

2024-02-15 | PXD033851 | Pride

Proteome of hippocampus after focal cerebral ischemia 1.5 h and reperfusion 24 h in mice

We obtained the profiles of neuronal proteome after cerebral ischemia and reperfusion by isolating mice hippocampus. Hippocampus combined from either nine sham or nine focal cerebral ischemia 1.5 h and reperfusion 24 h (IR) mice were lysed, digested, labeled with different TMT tags, then pooled and ...

ORGANISM(S): Mus musculus (Mouse)

2024-02-15 | PXD033938 | Pride

Proteome hippocampus cerebral ischemia and reperfusion

Proteomic analysis of whole blood to investigate the therapeutic effects of nervonic acid on cerebral ischemia-reperfusion injury in rats

ORGANISM(S): Rattus Norvegicus

2025-01-01 | PXD059362 |

Proteomic analysis of focal cerebral ischemia/reperfusion injury in rats

Stroke is a leading cause of mortality and long-term disability and ischemic stroke accounts for 87% of all strokes. Though timely recanalization of the occluded vessel is essential in the treatment of ischemic stroke, it is well known to cause ischemia-reperfusion (I/R) injury which result in neuro...

ORGANISM(S): Rattus norvegicus (Rat)

2019-07-03 | PXD012151 | Pride

Middle cerebral artery occlusion (mcao) Proteomics Rat Time course Brain stroke Ischemia-reperfusion injury

Transcription profiling of white and grey matter in the distribution on the middle cerebral artery 6 hours after administration of the saline/catalytic antioxidant AEOL 10150 and ischemia/reperfusion of the MCAO to study the effect of AEOL 10150 on gene expression.

A catalytic antioxidant (AEOL 10150) attenuates expression of inflammatory genes in stroke. White and grey matter in the distribution on the middle cerebral artery 6 hours after administration of the saline/catalytic antioxidant AEOL 10150 and ischemia/reperfusion of the MCAO; pooled mRNA from 6 bra...

ORGANISM(S): Mus musculus

2007-12-15 | E-GEOD-63 | biostudies-arrayexpress

Integrated multi-omics reveals gut microbiota–metabolic mechanisms underlying the neuroprotective effects of Xijiao Dihuang Decoction against cerebral ischemia–reperfusion injury

This study investigated the effects of Xijiao Dihuang Decoction (XDD) on cerebral ischemia–reperfusion injury using a middle cerebral artery occlusion/reperfusion rat model. Untargeted LC–MS metabolomics was performed on fecal samples to characterize metabolic alterations associated with MCAO/R and ...

2026-09-23 | MTBLS15783 | MetaboLights

Transcription profiling of mouse forebrain with induced middle cerebral artery occlusion (MCAO) to study permanent focal cerebral ischemia

profiling gene transcription in a mouse model of permanent focal cerebral ischemia that was induced by middle cerebral artery occlusion (MCAO)

ORGANISM(S): Mus musculus

2009-03-07 | E-TABM-655 | biostudies-arrayexpress

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