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MetabolomicsA metabolic switch orchestrated by IL-18 and the cyclic dinucleotide cGAMP programs intestinal tolerance
Tissues are exposed to diverse inflammatory challenges that shape future inflammatory responses. While cellular metabolism regulates immune function, how metabolism programs and stabilizes immune states within tissues and tunes susceptibility to inflammation is poorly understood. Here, we describe a...
2024-10-25 | MTBLS10416 | MetaboLights
ProteomicsA Phosphotriester-Masked Dideoxy-cGAMP Derivative as a Cell-Permeable STING Agonist
2’3’-cyclic GMP-AMP (cGAMP) is a cyclic dinucleotide second messenger in which guanosine and adenosine are connected by one 3’-5’ and one 2’-5’ phosphodiester linkage. It is formed in the cytosol upon detection of pathogenic DNA by the enzyme guanosine-monophosphate-adenosine monophosphate synthase ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD057395 | Pride
Sting Interferone Cgamp 
ProteomicsViruses antagonise expression and function of cGAMP transporters, channels and pores
DNA sensing is a fundamental process in the immune system, including host defence against viruses. The DNA sensor cGAS synthesises 2’3’ cyclic GMP-AMP (cGAMP), a second messenger that activates STING, which subsequently induces innate immunity. cGAMP not only activates STING in the cell where it is ...
ORGANISM(S): Homo sapiens (Human) 
2024-04-15 | PXD043229 | Pride
Na sensing  cgamp  cgamp transport  vrac  lrrc8a  slc46a2  p2x7  herpes simplex virus  ul56 
GenomicsRNAseq of 2'3' cGAMP injected Drosophila melanogaster
RNAseq of 2'3' cGAMP injected Drosophila melanogaster
PRJNA591568 | ENA
Genomics2’3’-cGAMP binds and activates Rab18 to promote cell migration
2’3’-cGAMP binds and activates Rab18 to promote cell migration
PRJNA865774 | ENA
Transcriptomics2’3’-cGAMP binds and activates Rab18 to promote cell migration
Cyclic dinucleotides serve as bacterial secondary messengers regulating sporulation, motility, biofilm formation and virulence. A nonsymmetric c-di-GAMP is firstly identified in bacteria to promote colonization, while mammalian 2’3’-cGAMP is synthesized by cGAS through binding and activating STING t...
ORGANISM(S): Homo sapiens 
2024-09-11 | GSE210490 | GEO
GenomicsActivation-induced SLC7A1 expression enhances T cell sensitivity to cGAMP-mediated STING signaling [U937_DOX_RNA_Seq]
Activation-induced SLC7A1 expression enhances T cell sensitivity to cGAMP-mediated STING signaling [U937_DOX_RNA_Seq]
PRJNA1441473 | ENA
GenomicsIntercellular cGAMP transmission induces innate immune activation and tissue inflammation in Trex1 deficiency
Intercellular cGAMP transmission induces innate immune activation and tissue inflammation in Trex1 deficiency
PRJNA735518 | ENA
GenomicsActivation-induced SLC7A1 expression enhances T cell sensitivity to cGAMP-mediated STING signaling [T_cells_RNA_Seq]
Activation-induced SLC7A1 expression enhances T cell sensitivity to cGAMP-mediated STING signaling [T_cells_RNA_Seq]
PRJNA1441475 | ENA
UnknownHuman SLC46A2 Is the Dominant cGAMP Importer in Extracellular cGAMP-Sensing Macrophages and Monocytes.
Not available
S-EPMC8228594 | biostudies-literature
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