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Metabolomics4-Octyl itaconate as a metabolite derivative inhibits inflammation via alkylation of STING

The Krebs cycle-derived metabolite itaconate, whose production is catalyzed by immune response gene 1 (IRG1), has excellent potential to link immunity and metabolism in activated macrophages through alkylation or competitive inhibition of target proteins. In support of this, our previous study de...

2023-01-15 | MTBLS5877 | MetaboLights
MetabolomicsLily polysaccharides alleviate colitis through the microbiota/N8AS/cGAS-STING signaling axis

With the rising incidence of IBD and limitations of current therapies, novel strategies are urgently needed. Recent studies have highlighted natural products in colitis treatment. Here, we investigated the therapeutic effects and mechanisms of lily polysaccharides (LP) in DSS-induced ulcerative c...

2025-09-29 | MTBLS13064 | MetaboLights
MetabolomicsThe Development of Metabolomic Markers in African Bermudagrass (C. transvaalensis) for Sting Nematode (Belonolaimus longicaudatus) Response
Not available
ORGANISM(S): Cynodon transvaalensis 
ST000353 | MetabolomicsWorkbench
ProteomicsVec-STING LS-MS and US2 STING LS-MS
Since US2 causes STING to be degraded through ubiquitination, we aimed to find any ubiquitin enzymes that might be implicated in this action.
ORGANISM(S): Homo sapiens (Human) 
2024-08-09 | PXD053353 | Pride
Sting Us2 
ProteomicsMass spectrometry analysis of proteins interacting with STING mutants
To investigate proteins interacting with STING mutants, HEK 293T cells were co-transfected with three STING mutant expression plasmids (human STING WT, STING delCTT (aa343-379 deletion), STING del6 (aa325-379 deletion) in a pcDNA3.1+ backbone) and either pcDNA-cGAS expression plasmid or control empt...
ORGANISM(S): Homo sapiens (Human) 
2024-02-19 | PXD038063 | Pride
Sting mutants Hek 293t Sting-interacting proteins Lc-ms/ms 
ProteomicsLFQ of streptavidin pulldown from hTBJ1 cells expressing APEX2-STING
Permeabilised hTBJ1 cells expressing APEX2-STING were stimulated with or without 1 μM cGAMP at 10°C and incubated for 1 min in the presence of 1 mM H2O2 and 50 µM biotin phenol. The reaction was then quickly stopped by washing three times with ice-cold 500 mM sodium ascorbate, followed by washing tw...
ORGANISM(S): Homo Sapiens (human) 
2022-12-09 | PXD029735 | JPOST Repository
TranscriptomicsActivation of STAT6 by STING Is Critical for Antiviral Innate Immunity
Analysis of the transcriptional response of HEK293 or HEK293-STAT6 stable cell lines to poly(I:C) transfection. The hypothesis tested was that poly(I:C) transfection is capable of inducing the expression of STAT6-dependent antiviral genes. mRNA isolated from HEK293 or HEK293-STAT6 stable cell lines ...
ORGANISM(S): Homo sapiens 
2011-11-21 | E-GEOD-26435 | biostudies-arrayexpress
ProteomicsSTING signalling is terminated through ESCRT-dependent microautophagy of vesicles originating from recycling endosomes
Stimulator of interferon genes (STING) is essential for the type I interferon response against a variety of DNA pathogens. Upon emergence of cytosolic DNA, STING translocates from the endoplasmic reticulum (ER) to the Golgi where STING activates the downstream kinase TBK1, then to lysosome through r...
ORGANISM(S): Mus musculus (Mouse) 
2023-01-24 | PXD039411 | Pride
Microautophagy Sting Escrt 
ProteomicsA novel HERC4-dependent glue degrader targeting STING
Stimulator of interferon genes (STING) is a central component of the pathway sensing the presence of cytosolic nucleic acids, having a key role in type I interferon innate immune response. Localized at the endoplasmic reticulum (ER), STING becomes activated by cGAMP, which is generated by the intrac...
ORGANISM(S): Homo sapiens (Human) 
2023-06-22 | PXD040291 | Pride
Targeted protein degradation Herc4 Glue degrader Tpd Sting 
ProteomicsSmall molecule induced STING degradation facilitated by the HECT ligase HERC4
Stimulator of interferon genes (STING) is a central component of the cytosolic nucleic acids sensing pathway and as such master regulator of the type I interferon response. Due to its critical role in physiology and its’ involvement in a variety of diseases, STING has been a focus for drug discovery...
ORGANISM(S): Homo sapiens (Human) 
2024-04-12 | PXD046677 | Pride
Targeted protein degradation Herc4 Tmt Mgd Glue degrader Tpd Sting 
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