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ProteomicsVec-STING LS-MS and US2 STING LS-MS
Since US2 causes STING to be degraded through ubiquitination, we aimed to find any ubiquitin enzymes that might be implicated in this action.
ORGANISM(S): Homo sapiens (Human) 
2024-08-09 | PXD053353 | Pride
Sting Us2 
GenomicsGaoshiqia
Gaoshiqia sp. strain US2 genome
PRJDB40412 | ENA
UnknownThe Us2 gene product of herpes simplex virus 2 is a membrane-associated ubiquitin-interacting protein.
Not available
S-EPMC3754132 | biostudies-literature
UnknownCyclophilin C Participates in the US2-Mediated Degradation of Major Histocompatibility Complex Class I Molecules.
Not available
S-EPMC4686535 | biostudies-literature
UnknownPseudorabies virus tegument protein US2 antagonizes antiviral innate immunity by targeting cGAS-STING signaling pathway.
Not available
S-EPMC11250390 | biostudies-literature
UnknownThe Us2 Gene Product of Herpes Simplex Virus 2 modulates NF-κB activation by targeting TAK1.
Not available
S-EPMC5566419 | biostudies-literature
UnknownThe UFM1 Pathway Impacts HCMV US2-Mediated Degradation of HLA Class I.
Not available
S-EPMC7827699 | biostudies-literature
UnknownAntigen presentation subverted: Structure of the human cytomegalovirus protein US2 bound to the class I molecule HLA-A2.
Not available
S-EPMC34432 | biostudies-literature
ProteomicsHCMV US2 co-opts TRC8 to degrade the ER-resident protein LMAN2L
The human cytomegalovirus (HCMV) pUS2 glycoprotein exploits the host’s endoplasmic reticulum (ER)-associated degradation (ERAD) pathway to degrade MHC class I and prevent antigen presentation. Beyond MHC class I, pUS2 has been shown to target a range of cellular proteins for degradation, preventing ...
ORGANISM(S): Homo sapiens (Human) 
2024-06-23 | PXD050878 | Pride
Cytomegalovirus Proteomics Protein trafficking Protein degradation Plasma membrane 
UnknownTRAM1 participates in human cytomegalovirus US2- and US11-mediated dislocation of an endoplasmic reticulum membrane glycoprotein.
Not available
S-EPMC2645836 | biostudies-literature
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