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MetabolomicsMetabolomics highlights reduced glutamate and acetylcarnitine in the amniotic fluid of cytomegalovirus-infected pregnant women

Cytomegalovirus (CMV) is a ubiquitous infectious agent that causes significant morbidity in immunosuppressed hosts and is the most common cause of neonatal congenital deafness.An infection acquired during pregnancy can be vertically transmitted to the fetus and cause permanent sequelae in the new...

2025-09-12 | MTBLS12415 | MetaboLights
MetabolomicsHuman Cytomegalovirus pUL37x1 is Important to Remodeling of Host Lipid Metabolism
Human cytomegalovirus (HCMV) replication requires host metabolism. Infection alters the activity in multiple metabolic pathways, including increasing fatty acid elongation and lipid synthesis. The virus-host interactions regulating the metabolic changes associated with replication are essential to i...
2020-06-26 | MTBLS1073 | MetaboLights
TranscriptomicsHigh-resolution profiling and analysis of viral and host small RNAs during human cytomegalovirus infection
Small RNA deep sequencing analysis was conducted on primary human fibroblasts infected with human cytomegalovirus (HCMV). HCMV-encoded miRNAs accumulated to ~20% of the total smRNA population at late stages of infection, and our analysis led to improvements in viral miRNA annotations and identificat...
ORGANISM(S): Homo sapiens 
2011-11-10 | E-GEOD-33584 | biostudies-arrayexpress
TranscriptomicsDecoding human cytomegalovirus using ribosome profiling
The human cytomegalovirus (HCMV) genome was sequenced 20 years ago. However, like other complex viruses, our understanding of its protein coding potential is far from complete. Here, we use ribosome profiling and transcript analysis to experimentally define the HCMV translation products and follow t...
ORGANISM(S): Human Herpesvirus 5 
2012-10-17 | E-GEOD-41605 | biostudies-arrayexpress
TranscriptomicsHuman induced pluripotent stem cell-technology to study the effects of human cytomegalovirus infection on neural differentiation
Congenital human cytomegalovirus (HCMV) infection is one of the leading prenatal causes of mental retardation and congenital deformities world-wide. Access to cultured human neuronal lineages, necessary to understand the species specific pathogenic effects of HCMV has been limited by difficulties i...
ORGANISM(S): Homo sapiens 
2013-01-04 | E-GEOD-35295 | biostudies-arrayexpress
TranscriptomicsFibroblast cells immediate-early after human cytomegalovirus infection
Human cytomegalovirus (HCMV) has been shown to have the potential to alter cellular gene expression early after infection. However, one-gene approaches and the use of closed system gene expression technologies have identified only few cellular genes whose activity changed immediate-early. We therefo...
ORGANISM(S): Homo sapiens 
2003-07-16 | E-GEOD-506 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human fetal gammadelta T cells from that cytomegalovirus (CMV) positive or negative
Response of fetal gammadelta T cells towards infection with human cytomegalovirus (CMV)
ORGANISM(S): Homo sapiens 
2009-12-12 | E-MEXP-2055 | biostudies-arrayexpress
MetabolomicsInfection-Induced Peroxisome Biogenesis Is a Metabolic Strategy for Herpesvirus Replication
Peroxisomes are primarily metabolic organelles with important functions in lipid metabolism, such as fatty acid oxidation and ether phospholipid synthesis (e.g. plasmalogens). Certain viruses, such as human cytomegalovirus (HCMV), hijack organelle functions to facilitate their replication and spread...
2018-10-22 | MTBLS652 | MetaboLights
TranscriptomicsHost cell gene expression late during cytomegalovirus infection
Human fibroblast monolayers plated at a density of 3 x 104 cells/cm2 in 850 cm2 roller bottles were infected at confluency (day 5 post-seeding) with purified virions of human cytomegalovirus (CMV) strain AD169varATCC (AD) or the AD169 US27/US28 deletion mutant virus RV101 (RV) at a multiplicity of i...
ORGANISM(S): Homo sapiens 
2005-08-25 | E-GEOD-3194 | biostudies-arrayexpress
TranscriptomicsRNA-Induced Silencing Complex-associated RNA in MRC-5 cells transfected with hcmv-miR-UL22A-5p
Investigation of mRNA targets of the human cytomegalovirus miRNA UL22A-5p One 4-plex chip was hybridized with cDNA originating from either total RNA or from AGO2-associated RNA (i.e. RISC-associated RNA) from fibroblasts transfected 48 hours earlier with hcmv-miR-UL22A-5p mimic or with a negative co...
ORGANISM(S): Homo sapiens 
2015-04-08 | E-GEOD-64503 | biostudies-arrayexpress
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