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ProteomicsPTPN23-dependent ESCRT machinery functions as a cell death checkpoint in restraining multiple cell death pathways
In our study, a CRISPR screen of acute myeloid leukemia cells identifies protein tyrosine phosphatase non-receptor type 23 (PTPN23) as essential for survival. Loss of PTPN23 activates nuclear factor-kappa B, apoptotic, necroptotic, and pyroptotic pathways by causing the accumulation of death recepto...
ORGANISM(S): Homo Sapiens 
PXD056836 |
ProteomicsLEM2 phase separation promotes ESCRT-mediated nuclear envelope reformation
Quantitative crosslinking analysis to probe in vitro conformational dynamics governing ESCRT-mediated nuclear envelope formation. CHMP7 was crosslinked with D12-BS3 while CHMP7 in the presence of LEM2 winged helix domain was crosslinked with H12-BS3. Samples were mixed after crosslinking and analy...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-01-24 | MSV000084837 | MassIVE
ProteomicsSelective microautophagy of proteasomes is initiated by ESCRT-0 and is promoted by proteasome ubiquitylation
The proteasome is central to proteolysis by the ubiquitin-proteasome system under normal growth conditions but is itself degraded through macroautophagy under nutrient stress. A recently described AMPactivated protein kinase (AMPK)-regulated endosomal sorting complex required for transport (ESCRT)-d...
ORGANISM(S): Saccharomyces Cerevisiae 
2022-02-06 | PXD031469 |
ProteomicsESCRT complexes in Giardia intestinalis (VPS36A)
To assess ESCRT subunit presence, distribution and main interactors, we performed iterative co-immunoprecipitation on recombinant Giardia subunits.
ORGANISM(S): Giardia lamblia ATCC 50803 
2021-04-10 | PXD016446 | Pride
Giardia Coip Escrt 
ProteomicsESCRT complexes in Giardia intestinalis (VPS25)
To assess ESCRT subunit presence, distribution and main interactors, we performed iterative co-immunoprecipitation on recombinant Giardia subunits.
ORGANISM(S): Giardia lamblia ATCC 50803 
2021-04-10 | PXD016448 | Pride
Giardia Coip Escrt 
ProteomicsESCRT complexes in Giardia intestinalis (VPS20L)
To access ESCRT subunit presence, distribution and main interactors, we performed iterative co-immunoprecipitation on recombinant Giardia subunits.
ORGANISM(S): Giardia lamblia ATCC 50803 
2021-04-10 | PXD016442 | Pride
Giardia Coip Escrt 
ProteomicsESCRT complexes in Giardia intestinalis (CHMP7)
To access ESCRT subunit presence, distribution and main interactors, we performed iterative co-immunoprecipitation on recombinant Giardia subunits.
ORGANISM(S): Giardia lamblia ATCC 50803 
2021-04-10 | PXD016487 | Pride
Giardia Coip Escrt 
ProteomicsIdentification of ESCRT-related subunits in Trypanosoma brucei
Using cryomilling and proteomics approaches we expand the understanding of ESCRT-I complex in Trypanosoma brucei. We found two novel subunits of the trypanosoma complex using TbVPS23 as bait.
ORGANISM(S): Trypanosoma brucei 
2026-08-24 | PXD058826 | Pride
Trypanosoma Co-immunoprecipitation Vps23 Cryomilling Escrt-i (endosomal sorting complex required for transport-i) 
GenomicsLASER couples damage sensing to ESCRT assembly for lysosome repair
LASER couples damage sensing to ESCRT assembly for lysosome repair
PRJNA1455520 | ENA
GenomicsESCRT-mediated machinery directly drives cardiac T-tubule formation
ESCRT-mediated machinery directly drives cardiac T-tubule formation
PRJNA1153460 | ENA
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