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ProteomicsSmall molecule induced STING degradation facilitated by the HECT ligase HERC4
Stimulator of interferon genes (STING) is a central component of the cytosolic nucleic acids sensing pathway and as such master regulator of the type I interferon response. Due to its critical role in physiology and its’ involvement in a variety of diseases, STING has been a focus for drug discovery...
ORGANISM(S): Homo sapiens (Human) 
2024-04-12 | PXD046677 | Pride
Targeted protein degradation Herc4 Tmt Mgd Glue degrader Tpd Sting 
ProteomicsA novel HERC4-dependent glue degrader targeting STING
Stimulator of interferon genes (STING) is a central component of the pathway sensing the presence of cytosolic nucleic acids, having a key role in type I interferon innate immune response. Localized at the endoplasmic reticulum (ER), STING becomes activated by cGAMP, which is generated by the intrac...
ORGANISM(S): Homo sapiens (Human) 
2023-06-22 | PXD040291 | Pride
Targeted protein degradation Herc4 Glue degrader Tpd Sting 
GenomicsHERC4-mediated ubiquitination licenses RIPK1 to initiate TNF-induced cell death
HERC4-mediated ubiquitination licenses RIPK1 to initiate TNF-induced cell death
PRJNA1418570 | ENA
OtherHERC4-mediated ubiquitination licenses RIPK1 to initiate TNF-induced cell death
TNF can activate both pro-survival and pro-death signaling downstream of tumor necrosis factor receptor 1 (TNFR1). Survival signaling originates from TNFR1-containing membrane-bound Complex I, while death signaling is driven by cytosolic Complex II. RIPK1 is a central component of both complexes, bu...
ORGANISM(S): Homo sapiens 
2026-07-14 | GSE318316 | GEO
UnknownA miRNA-HERC4 pathway promotes breast tumorigenesis by inactivating tumor suppressor LATS1.
Not available
S-EPMC6626598 | biostudies-literature
UnknownHippo Stabilises Its Adaptor Salvador by Antagonising the HECT Ubiquitin Ligase Herc4.
Not available
S-EPMC4488328 | biostudies-literature
UnknownE3 ligase Herc4 regulates Hedgehog signalling through promoting Smoothened degradation.
Not available
S-EPMC7261483 | biostudies-literature
UnknownHERC4 downregulates KRT19 to promote lung adenocarcinoma, migration, invasion and EMT.
Not available
S-EPMC12630102 | biostudies-literature
UnknownSmall molecule induced STING degradation facilitated by the HECT ligase HERC4.
Not available
S-EPMC11137104 | biostudies-literature
ProteomicsHERC4 suppresses colorectal cancer progression
Our study aims to identify the enzymes that interact with STAT3 and the specific sites where STAT3 undergoes ubiquitination modification.
ORGANISM(S): Homo Sapiens 
PXD077280 |
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