HERC4 downregulates KRT19 to promote lung adenocarcinoma, migration, invasion and EMT.

ABSTRACT:

Background

Metastasis is a major cause of treatment failure and poor prognosis in lung adenocarcinoma (LUAD). Epithelial-mesenchymal transition (EMT) plays a crucial role in promoting LUAD metastasis. Pulmonary sarcomatoid carcinoma (PSC), a highly aggressive non-small cell lung cancer subtype, contains both carcinomatous component (CaC) and sarcomatous component (SaC) with strong metastatic potential. Previous studies have shown that EMT contributes to the formation of Sac in PSC.

Methods

The differential expression of KRT19 between SaC and CaC in PSC was screened and validated using immunohistochemistry. GO, KEGG analysis were conducted to investigate the potential mechanism of KRT19. The CCK-8, wound healing, transwell assay and mouse model were used to confirm the impact

SUBMITTER: Sun HJ 

PROVIDER: S-EPMC12630102 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature