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ProteomicsIntricate structure of the interphase chromocenter revealed by the analysis of a factor involved in species formation
In higher eukaryotes centromeres often coalesce into a large intranuclear domain called the chromocenter. Chromocenters are important for the organization of pericentric heterochromatin and a disturbance of their formation results in an upregulation of repetitive elements and causes defects in chrom...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2020-03-23 | PXD012551 | Pride
Chromatin proteomics Drosophila Chromocenter Centromeres 
ProteomicsEIF5A couples translational control with transcriptional reprogramming through chromocenter reorganization during spermiogenesis
Translation initiation factor eIF5A facilitates protein synthesis and impacts diverse biological processes, yet its role in transcriptional regulation is poorly understood. Here we find eIF5A highly expressed in diverse spermatogenic cell types. Conditional knockout of Eif5a (SKO) causes complete in...
ORGANISM(S): Mus Musculus 
PXD067244 |
GenomicsIntricate structure of the interphase chromocenter revealed by proximity based biotinylation
Intricate structure of the interphase chromocenter revealed by proximity based biotinylation
PRJNA564796 | ENA
UnknownThe modular mechanism of chromocenter formation in Drosophila.
Not available
S-EPMC6382350 | biostudies-literature
UnknownA multi-layered structure of the interphase chromocenter revealed by proximity-based biotinylation.
Not available
S-EPMC7192626 | biostudies-literature
UnknownTet1 regulates epigenetic remodeling of the pericentromeric heterochromatin and chromocenter organization in DNA hypomethylated cells.
Not available
S-EPMC8263065 | biostudies-literature
UnknownEIF5A Couples Translational Control With Transcriptional Reprogramming Through Chromocenter Reorganization During Spermiogenesis.
Not available
S-EPMC12903998 | biostudies-literature
GenomicsIntricate structure of the interphase chromocenter revealed by proximity based biotinylation
During interphase centromeres often coalesce into a small number of chromocenters, which can be visualized as distinct, DAPI dense nuclear domains. Intact chromocenters play a major role in maintaining genome stability as they stabilize the transcriptionally silent state of repetitive DNA while ensu...
ORGANISM(S): Drosophila melanogaster 
2020-01-01 | GSE137194 | GEO
GenomicsEIF5A couples translational control with transcriptional reprogramming through chromocenter reorganization during spermiogenesis [ATAC-Seq]
EIF5A couples translational control with transcriptional reprogramming through chromocenter reorganization during spermiogenesis [ATAC-Seq]
PRJNA1292817 | ENA
GenomicsEIF5A couples translational control with transcriptional reprogramming through chromocenter reorganization during spermiogenesis [Ribo-Seq]
EIF5A couples translational control with transcriptional reprogramming through chromocenter reorganization during spermiogenesis [Ribo-Seq]
PRJNA1292810 | ENA
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