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TranscriptomicsChromatin immunopreciptiation of human mesenchymal stem cells during osteogenic differentiation to identify histone H3 lysine9 modifications
In this study, full human genome promoter microarrays and expression microarrays were used to explore the roles of histone modifications (H3K9Ac and H3K9Me2) upon the induction of MSC osteogenic differentiation.
ORGANISM(S): Homo sapiens 
2009-04-14 | E-MEXP-2134 | biostudies-arrayexpress
ProteomicsCharacterization of the Angiogenic and Proteomic Features of Circulating Exosomes in a Canine Mandibular Model of Distraction Osteogenesis
While distraction osteogenesis (DO) can be an extremely effective approach to treating extensive bone defects, it entails a very long treatment period. The present study was designed with the goal of clarifying the mechanisms underlying the angiogenic and osteogenic activities characteristic of DO s...
ORGANISM(S): Canis familiaris (Dog) (Canis lupus familiaris) 
2025-05-13 | PXD050531 | Pride
Characterization Circulating exosomes Proteomic Angiogenic Distraction osteogenesis 
GenomicsEWS-FLI1-induced osteosarcoma model unveiled a crucial role of impaired osteogenic differentiation on osteosarcoma development [ChIP-seq]
EWS-FLI1, a multi-functional fusion oncogene, is exclusively detectable in Ewing sarcomas. However, previous studies reported that a subset of osteosarcomas also harbor EWS-ETS family fusion, suggesting that the fusion gene may be involved in the development of a particular type of osteosarcomas. He...
ORGANISM(S): Mus musculus 
2016-03-01 | E-GEOD-72897 | biostudies-arrayexpress
ProteomicsIntegrative transcriptomic and proteomic analysis show circulating osteoprogenitors to have a mixed immune and mesenchymal progenitor function in humans
Circulating osteoprogenitor (COP) are a population of cell in the peripheral circulation that possess functional and phenotypical characteristics of multipotent stromal cells (MSCs). While there is functional overlap, it is not known how COP cells are related to bone marrow (BM)-derived MSCs (BM-MSC...
ORGANISM(S): Homo sapiens (Human) 
2024-10-17 | PXD035803 | Pride
Circulating osteoprogenitor cell  circulating osteogenic precursor  multilineage stromal cells  adipose-derived stromal cells. 
UnknownCirculating osteogenic progenitors and osteoclast precursors are associated with long-term glycemic control, sex steroids, and visceral adipose tissue in men with type 2 diabetes mellitus.
Not available
S-EPMC9511027 | biostudies-literature
OtherCharacterization of functional reprogramming during osteoclast development using quantitative proteomics and mRNA profiling.
Data from ProteomeXchange, PXD ID: PXD000471. Experiment: 101207_EA_E, file: 101215_EA_E13.mzml. Published as part of . From the Abstract: {{i}} In addition to forming macrophages and dendritic cells, monocytes in adult peripheral blood retain the ability to develop into osteoclasts, mature bone-re...
ORGANISM(S): Mus_musculus_viruses, Mouse 
GPM11210028860 | GPMDB
Resource Reanalysis 
TranscriptomicsEpigenetic screen of metastasis-driving genes in osteosarcoma
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2015-08-25 | E-GEOD-56255 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse kidney from FGF23, TG and WT mice
Fibroblast growth factor-23 (FGF23), a circulating protein produced in bone, causes renal inorganic phosphate (Pi) wasting by down-regulation of sodium phosphate co-transporter 2a (Npt2a). The mechanism behind this action is unknown. We have previously generated transgenic mice (TG) expressing human...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-6979 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human Mesenchymal Stem Cells (MSC) vs reference RNA of non-multipotent human fibroblasts HS68
Mesenchymal stem cells (MSC) resemble a multipotent adult stem cell population capable of differentiation into a number of different mesodermal cell types including adipodytes, osteoblasts, chondroblasts. Although still in debate there is some evidence, that these cells can also differentiate into c...
ORGANISM(S): Homo sapiens 
2005-08-23 | E-EMBL-4 | biostudies-arrayexpress
MetabolomicsParabacteroides distasonis Improving osteoporosis progression through glycerophospholipid metabolism_blood

Backround&Aim: Dysbiosis of gut microbiota is closely related to the pathogenesis of osteoporosis (OP). This study aimed to identify probiotic candidates and gut-derived metabolites capable of ameliorating osteoporosis via modulation of bone metabolism. 

Methods: Ovariect...

2025-08-01 | MTBLS12803 | MetaboLights
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