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TranscriptomicsGene expression changes associated with the anti-angiogenic effect of KLK3 (PSA) on HUVECs
Kallikrein-related peptidase 3 (KLK3, also known as prostate-specific antigen, PSA) is a chymotrypsin-like kallikrein that has been shown to have anti-angiogenic properties. KLK3 expression in prostate cancer is associated with low microvessel density. We have previously shown in a human umbilical v...
ORGANISM(S): Homo sapiens 
2010-06-25 | E-GEOD-9869 | biostudies-arrayexpress
TranscriptomicsSlit2 modifies VEGF-induced angiogenic responses in rabbit skeletal muscle by inducing capillary sprouting and decreasing vascular permeability via reduced eNOS activity
Rationale: Slit2 is a possible modulator of vascular endothelial growth factor (VEGF) - induced angiogenesis, but its effects have not been tested in large animal models. Objective: We studied the effect of Slit2 on therapeutic angiogenesis induced by VEGF receptor 2 (VEGFR2) ligands Vammin and VEGF...
ORGANISM(S): Homo sapiens 
2015-05-26 | E-GEOD-63283 | biostudies-arrayexpress
ModelsYazdjer2019 - reinforcement learning-based control of tumor growth under anti-angiogenic therapy
This model is based on: Reinforcement learning-based control of tumor growth under anti-angiogenic therapy Authors: Parisa Yazdjerdi, Nader Meskin, Mohammad Al-Naemi, Ala-Eddin Al Moustafa, Levente Kovacs Abstract: Background and objectives: In recent decades, cancer has become one of the most fata...
2024-09-02 | BIOMD0000000821 | BioModels
TranscriptomicsTranscription profiling of human dormant and angiogenic breast cancer, osteosarcoma, liposarcoma and brain tumor cell lines
The Goal of this study is to explore the transcriptional differences between angiogenic and non-angiogenic tumors generated in Dr. Folkman's Lab, Harvard Medical School.
Referneces:
Almog N, Henke V, Flores L, Hlatky L, Kung AL, Wright RD, Berger R, Hutchinson L, Naumov GN, Bender E, Akslen LA...
ORGANISM(S): Homo sapiens 
2009-02-03 | E-TABM-390 | biostudies-arrayexpress
ProteomicsAtherosclerotic environment effect over CAC pre-angiogenic role
In response to vascular injury, early EPC or Circulating angiogenic cells (CAC) are thought to be recruited to the damaged areas, participating mainly in a paracrine fashion, by releasing pro-angiogenic factors, promoting the mobilization of other cell populations such as the late EPC, or endothelia...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD019395 | Pride
Proteomics Angiogenesis Circulating angiogenic cells Atherosclerotic factors Paracrine role Endothelial colony forming cells Secretome 
ProteomicsExtracellular vimentin mimics VEGF and is a target for anti-angiogenic immunotherapy
Anti-angiogenic anticancer therapies possess immune-stimulatory properties by counteracting pro-angiogenic molecular mechanisms. We report that tumor endothelial cells ubiquitously overexpress and secrete the intermediate filament protein vimentin through type III unconventional mechanisms. Extracel...
ORGANISM(S): Homo sapiens (Human) 
2022-03-29 | PXD024426 | Pride
Vegf Angiogenesis Human Vimentin Cancer Anti-angiogenic therapy 
TranscriptomicsInfection of Myeloid Angiogenic Cells (MACs) with Bartonella henselae (B.h.) induces a chord formation phenotype in vitro.
Myeloid Angiogenic Cells (MACs) were infected with the intracellular, bacterial pathogen Bartonella henselae (B.h.). Infected cells were seeded onto Matrigel coated plates. While uninfected cells showed no phenotypic changes and died over time, infected cells showed strong phenotypic changes and dev...
ORGANISM(S): Homo sapiens 
2015-04-23 | E-GEOD-55170 | biostudies-arrayexpress
ProteomicsCharacterization of the Angiogenic and Proteomic Features of Circulating Exosomes in a Canine Mandibular Model of Distraction Osteogenesis
While distraction osteogenesis (DO) can be an extremely effective approach to treating extensive bone defects, it entails a very long treatment period. The present study was designed with the goal of clarifying the mechanisms underlying the angiogenic and osteogenic activities characteristic of DO s...
ORGANISM(S): Canis familiaris (Dog) (Canis lupus familiaris) 
2025-05-13 | PXD050531 | Pride
Characterization Circulating exosomes Proteomic Angiogenic Distraction osteogenesis 
TranscriptomicsExpression analysis of the glucose deprivation-induced human tumor cell responses
The tumor microenvironment is characterized by low glucose and hypoxia. It is well known that changes in the tumor microenvironment, such as hypoxia and low glucose, can increase the production of VEGF. Although the role of hypoxia in the regulation of VEGF production is well understood, the mechani...
ORGANISM(S): Homo sapiens 
2012-10-25 | E-GEOD-38583 | biostudies-arrayexpress
ProteomicsLong-term changes following pre-conditioned circulating angiogenic cells therapy in critical limb ischemia
Critical limb ischemia (CLI), results from a severe blockade of the arterial vessels, is usually correlated to atherosclerosis. Circulating angiogenic cells (CACs) constitute a good alternative as CLI cell therapy due to their vascular regenerative potential, although the mechanisms of action of the...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-16 | PXD024132 | Pride
Neovascularization Circulating angiogenic cells Immune cells Atherosclerotic secretome Critical limb ischemia 
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