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TranscriptomicsSex-specific control of CNS autoimmunity by p38 MAPK signaling in myeloid cells
Objective: Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS), characterized by a global increasing incidence driven by relapsing-remitting disease in females. p38 MAP kinase (MAPK) has been described as a key regulator of inflammatory respons...
ORGANISM(S): Mus musculus 
2013-10-29 | E-GEOD-51707 | biostudies-arrayexpress
TranscriptomicsThe CNS-Heart Axis is a Source of Cardiac Dysfunction in Mouse Models of Huntington's Disease
Purpose: Transcriptome profiling (RNA-seq) to microarray to evaluate transcriptional changes in the heart of HD mouse models Methods: Heart mRNA profiles of 4-weeks-old wild-type (WT) and R6/2 transgenic; 15-weeks-old WT and R6/2 transgenic mice; 8-month-old WT and HdhQ150 knock-in mice; 22-month-ol...
ORGANISM(S): Mus musculus 
2014-07-15 | E-GEOD-58996 | biostudies-arrayexpress
ProteomicsInnate immunocompetent iNSpheroids: A hiPSC-derived 3D model to study the central nervous system captures an early CNS response to rAAV
Gene therapies using adeno-associated viruses (AAVs) for central nervous system (CNS) disorders face challenges due to host immune responses not represented in classical preclinical models. Here, we present a human-induced pluripotent stem cell (hiPSC)-derived innate immunocompetent 3D CNS model tha...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD065639 | Pride
Gene therapy  neuroinflammation  cns models  glial cells 
ProteomicsThe CNS myelin proteome: Deep profile and persistence after post-mortem delay
We revisited the proteome of myelin biochemically purified from the brains of healthy c56Bl/6N-mice utilizing complementary proteomic approaches for deep qualitative and quantitative coverage. A data-independent acquisition (DIA) workflow with alternating low and elevated energy (MSE) provided the h...
ORGANISM(S): Mus musculus (Mouse) 
2020-07-16 | PXD020007 | Pride
Mass spectrometry Oligodendrocyte Proteolipid protein (plp) Central nervous system (cns) Label-free proteomics Myelin basic protein (mbp) Post mortem-delay Cyclic nucleotide phosphodiesterase (cnp) Myelin proteome Transcriptome Demyelination Autopsy 
TranscriptomicsQuality assessment and control of tissue specific RNA-seq libraries of Drosophila transgenic RNAi models
Next-generation RNA-sequencing (RNA-seq) is rapidly emerging as the technology of choice for whole-transcriptome studies. However, RNA-seq is not a bias free technique. It requires large amounts of RNA and library preparation can introduce multiple artifacts, compounded by problems from later stages...
ORGANISM(S): Drosophila melanogaster 
2014-04-01 | E-GEOD-54724 | biostudies-arrayexpress
GenomicsAddressing human astrogliosis in a human iPSC-derived 3D CNS model
Addressing human astrogliosis in a human iPSC-derived 3D CNS model
PRJNA1017481 | ENA
GenomicsGenome-wide in vivo CNS Screening Identifies Genes that Modify CNS Neuronal Survival and mHTT Toxicity
Genome-wide in vivo CNS Screening Identifies Genes that Modify CNS Neuronal Survival and mHTT Toxicity
PRJNA594969 | ENA
TranscriptomicsMB_xenograft_models
Classification of medulloblastoma xengrafts models primary human patient medulloblastoma samples were implanted into the corresponding position in SCID mice, the subsequent tumors gene expression profiles were compared with those of primary tumor samples to see if the overall transcriptomes were pre...
ORGANISM(S): Homo sapiens 
2012-04-04 | E-GEOD-28192 | biostudies-arrayexpress
UnknownNeuroprotective effects of estrogen in CNS injuries: insights from animal models.
Not available
S-EPMC5567743 | biostudies-literature
TranscriptomicsBioinformatics Analyses Determined the Distinct CNS and Peripheral Surrogate Biomarker Candidates between Two Mouse Models for Progressive Multiple Sclerosis
Previously, we have established two distinct progressive multiple sclerosis (MS) models by induction of experimental autoimmune encephalomyelitis (EAE) with myelin oligodendrocyte glycoprotein (MOG) in two mouse strains. A.SW mice develop ataxia with antibody deposition, but no T cell infiltration, ...
ORGANISM(S): Mus musculus 
2019-04-09 | GSE99300 | GEO
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