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TranscriptomicsTREM2 regulates microglial cell activation in response to demyelination in vivo
Microglia are phagocytic cells that survey the brain and perform neuroprotective functions in response to tissue damage, but their activating receptors are largely unknown. Triggering receptor expressed on myeloid cells 2 (TREM2) is a microglial immunoreceptor whose loss-of-function mutations in hum...
ORGANISM(S): Mus musculus 
2015-07-06 | E-GEOD-70475 | biostudies-arrayexpress
TranscriptomicsGene expression after focal demyelination of the corpus callosum
To determine expression profiles of cytokines and growth factor profiles in the subventricular zone (SVZ) after demyelination we performed gene array analysis. In SVZ after 4 days post lesin (dpl) LPC-injected tissue, demonstrated regulation of BMP pathway elements, including increased chordin, nogg...
ORGANISM(S): Mus musculus 
2010-04-13 | E-GEOD-21310 | biostudies-arrayexpress
TranscriptomicsExpression data from WT and TREM2 deficient microglia in response to cuprizone mediated demyelination
We examined the role of TREM2 on microglia responses to demyelination Microglia were FACS-purified from WT or Trem2-/- mice fed with 0.2% cuprizone diet.
ORGANISM(S): Mus musculus 
2015-04-22 | E-GEOD-66926 | biostudies-arrayexpress
TranscriptomicsTranscriptional changes in demyelinating canine distemper virus encephalitis
Canine distemper virus (CDV)-induced demyelinating leukoencephalitis (CDV-DL) in dogs is a translational animal model for human demyelinating diseases such as multiple sclerosis. The aim of this study was to perform an assumption-free microarray analysis of gene expression in different subgroups of ...
ORGANISM(S): Canis familiaris 
2014-04-23 | E-MEXP-3917 | biostudies-arrayexpress
Transcriptomicssubventricular zone progenitors healthy vs. Experimental Autoimmune Encephalomyelitis mice
Transcriptional profiling of subventricular zone (SVZ) progenitors comparing control healthy mice to mice induced to develop an autoimmune demyelination (EAE model). Goal was to unveil genes involved in demyelination-induced reactivity of SVZ progenitors. Two-condition experiment, healthy vs. EAE de...
ORGANISM(S): Mus musculus 
2013-09-09 | E-GEOD-47486 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse spinal cord from mock-infected and Theilers murine encephalomyelitis (TME)-virus infected animals - time series
Theiler’s murine encephalomyelitis (TME) is an experimentally virus-induced demyelinating leukomyelitis, displaying clinical and pathological similarities to chronic progressive multiple sclerosis.
The aim of this study was to identify pathways associated with demyelination using an assumption-f...
ORGANISM(S): Mus musculus 
2009-06-19 | E-MEXP-1717 | biostudies-arrayexpress
GenomicsDemyelination-Induced Glutamatergic Imbalance Mediates Hippocampal Hyperexcitability
Demyelination-Induced Glutamatergic Imbalance Mediates Hippocampal Hyperexcitability
PRJNA1333491 | ENA
TranscriptomicsX-linked adrenoleukosdystrophy disease X-ALD
X-linked adrenoleukodystrophy (X-ALD) is a metabolic genetic disorder of the central nervous system characterized by axonopathy in spinal cords, progressive demyelination in the brain and adrenal insufficiency. Here we provide transcriptomic data from white matter of human X-ALD patients compared to...
ORGANISM(S): Homo sapiens 
2012-03-21 | E-MEXP-3288 | biostudies-arrayexpress
GenomicsSuppressing PRKG2 alleviates demyelination in neurological disorders
Suppressing PRKG2 alleviates demyelination in neurological disorders
PRJNA1461823 | ENA
ProteomicsProteomic changes in cuprizone induced remyelination and demyelination processes.
The MS raw files were processed and search in Mascot and SEQUEST through the Proteome Discoverer 2.1 software (Thermo Fisher Scientific). Database searches were performed using the following parameters: Precursor mass tolerance of 10 parts per million (ppm); MSMS mass tolerance of 0.05 Da; Enzyme: T...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2019-03-01 | MSV000083506 | MassIVE
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