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MetabolomicsDifferent regions of synaptic vesicle membrane regulate VAMP2 conformation for the SNARE assembly
Vesicle associated membrane protein 2 (VAMP2/synaptobrevin2), a core SNARE protein residing on synaptic vesicles (SVs), forms helix bundles with syntaxin-1 and SNAP25 for the SNARE assembly. Prior to the SNARE assembly, the structure of VAMP2 is unclear. Here, by using in-cell NMR spectroscopy, we d...
2021-10-06 | MTBLS1503 | MetaboLights
TranscriptomicsTissue-specific changes in Tcrb conformation
We report the changes in Tcrb interactome upon transitioning from DN to DP stage of thymocyte development Examination of the interactomes of Eb and Trbv5 viewpoints in RAG-deficient DN and DP thymocytes
ORGANISM(S): Mus musculus 
2015-07-08 | E-GEOD-68955 | biostudies-arrayexpress
GenomicsOncogene-Mediated Alterations in Chromatin Conformation
Emerging evidence suggests that chromatin adopts a non-random three-dimensional (3D) topology and that the organization of genes into structural hubs and domains affects their transcriptional status. How chromatin conformation changes in diseases such as cancer is poorly understood. Moreover, how on...
ORGANISM(S): Homo sapiens 
2012-05-23 | E-GEOD-37752 | biostudies-arrayexpress
MetabolomicsThe gut microbiota contributes to changes in the host immune response induced by Trichinella spiralis
The gut microbiota plays an important role in parasite-host interactions and the induction of immune defense responses. Trichinella spiralis is an important zoonotic parasite that can directly or indirectly interact with the host in the gut. Changes in the gut microbiota following infection with T. ...
2023-08-07 | MTBLS7603 | MetaboLights
MetabolomicsEVOLUTION OF THE LIPIDOME UNCOVERS EARLY CHANGES IN ADRENOLEUKODYSTROPHY HUMAN CORTICAL AND SPINAL ORGANOIDS

Lipids are critical for the structure, signaling, and metabolism of the central nervous system (CNS), yet their roles during human brain development remain underexplored due to limited tissue availability. X-linked adrenoleukodystrophy (ALD), a peroxisomal disorder caused by ABCD1 mutat...

2025-11-17 | MTBLS12973 | MetaboLights
GenomicsChromatin conformation remains stable upon extensive transcriptional changes driven by heat shock [S2]
Chromatin conformation remains stable upon extensive transcriptional changes driven by heat shock [S2]
PRJNA541321 | ENA
GenomicsChromatin conformation remains stable upon extensive transcriptional changes driven by heat shock [K562]
Chromatin conformation remains stable upon extensive transcriptional changes driven by heat shock [K562]
PRJNA541309 | ENA
TranscriptomicsGenome-wide translational changes induced by the prion [PSI+]
Prions are infectious proteins that can adopt a structural conformation different from that of the normal protein. This change of conformation is then propagated among other molecules of the same protein. Prions are associated with neurodegenerative diseases in mammals, but are also found in fungi (...
ORGANISM(S): Saccharomyces cerevisiae 
2014-07-18 | E-GEOD-41590 | biostudies-arrayexpress
TranscriptomicsPrimary monocyte to macrophage differentiation involves significant changes in chromosome conformation different from cultured THP-1 cells
Use human native monocyte and induce to macrophae by GM-CSF, reserach the chromatin conformation of these two cell types.
ORGANISM(S): Homo sapiens 
2021-02-23 | E-MTAB-8262 | biostudies-arrayexpress
GenomicsPioneer factor Foxa2 mediates chromatin conformation changes in ligand-dependent activation of nuclear receptor FXR
Pioneer factor Foxa2 mediates chromatin conformation changes in ligand-dependent activation of nuclear receptor FXR
PRJNA952640 | ENA
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