Oncogene-Mediated Alterations in Chromatin Conformation

ABSTRACT: Emerging evidence suggests that chromatin adopts a non-random three-dimensional (3D) topology and that the organization of genes into structural hubs and domains affects their transcriptional status. How chromatin conformation changes in diseases such as cancer is poorly understood. Moreover, how oncogenic transcription factors, which bind to thousands of sites across the genome, influence gene regulation by globally altering the topology of chromatin requires further investigation. To address these questions, we performed unbiased high-resolution mapping of intra- and inter-chromosome interactions upon over-expression of ERG, an oncogenic transcription factor frequently over-expressed in prostate cancer as a result of a gene fusion. By integrating data from genome-wide chromosome conforma

ORGANISM(S): Homo sapiens

SUBMITTER: David Soong 

PROVIDER: E-GEOD-37752 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress