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MetabolomicsMolecular profiling of sponge movement reveals an ancient contractile-inflammatory response

A hallmark of animals is the coordination of whole-body movement. Neurons and muscles are central to this; yet, coordinated movements also exist in sponges that lack these cell types. Sponges are sessile animals with a complex canal system for filter-feeding. They undergo whole-body movements res...

2026-08-11 | MTBLS8137 | MetaboLights
MetabolomicsActivation of IRF3 in cardiomyocytes impairs mitochondrial oxidative function through PGC-1α inhibition and drives heart failure

Heightened sterile inflammation and mitochondrial metabolic dysfunction drives the pathophysiology of heart failure in ischemic cardiomyopathy. Yet, the transcriptional regulators within cardiomyocytes driving crosstalk between inflammation and energy metabolism remain ill-defined. Here we identi...

2026-01-28 | MTBLS13783 | MetaboLights
ProteomicsSeptin 7 Interacts With Numb To Preserve Sarcomere Structural Organization And Muscle Contractile Function
Here, we investigated mechanisms by which aging-related reductions of the levels of Numb in skeletal muscle fibers contribute to loss of muscle strength and power, two critical features of sarcopenia. Numb is an adaptor protein best known for its critical roles in development including asymmetric ce...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-04-28 | MSV000089327 | MassIVE
TranscriptomicsMicroarray skeletal muscle miR-499 overexpressing mice
This experiment was conducted to identify target genes of the microRNA-499 in skeletal muscle of transgenic mice that overexpressed miR-499. The following abstract from the submitted manuscript describes the major findings of this work. Coupling of mitochondrial function and skeletal muscle f...
ORGANISM(S): Mus musculus 
2016-09-03 | E-GEOD-72581 | biostudies-arrayexpress
GenomicsRegulation of Collecting Lymphatic Vessel Contractile Function by TRPV4 Channels
Regulation of Collecting Lymphatic Vessel Contractile Function by TRPV4 Channels
PRJNA1251083 | ENA
TranscriptomicsTranscription profiling of mouse SRF-null or control cardiomyocytes to study roles of the serum response factor in regulating contractile apparatus gene expression.
Serum Response Factor (SRF) is a transcriptional regulator required for mesodermal development. Numerous studies have implicated SRF as a central regulator of muscle gene expression and myogenesis. In this present study we used a loss of function approach to delineate the role of SRF in cardiac myoc...
ORGANISM(S): Mus musculus 
2007-09-07 | E-GEOD-3181 | biostudies-arrayexpress
Proteomicsp300 and CBP are essential for skeletal muscle homeostasis, contractile function and survival
Reversible epsilon-amino acetylation of lysine residues regulates transcription as well as metabolic flux; however, roles for specific lysine acetyltransferases in skeletal muscle physiology and function remain enigmatic. In this study, we investigated the role of the homologous acetyltransferases p...
ORGANISM(S): Mus musculus (Mouse) 
2020-04-03 | PXD015694 | Pride
Proteomics Muscle contraction Acetyltransferases Acetylation Transcriptomics 
ProteomicsExtracellular matrix downregulation in the Drosophila heart preserves contractile function and improves lifespan
Aging is associated with extensive remodeling of the heart, including basement membrane (BM) components that surround cardiomyocytes. Remodeling is thought to impair cardiac mechanotransduction, but the contribution of specific BM components to age-related lateral communication between cardiomyocyte...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2017-03-27 | PXD006120 | Pride
Basement membrane Laminin a Aging Extracellular matrix Drosophila 
Genomicsp300 and CBP are essential for skeletal muscle homeostasis, contractile function and survival
p300 and CBP are essential for skeletal muscle homeostasis, contractile function and survival
PRJNA594968 | ENA
TranscriptomicsIdentification of target genes of myostatin loss-of-function in the muscle of bovine fetuses
Myostatin is a highly conserved Transforming Growth Factor beta family member which negatively regulates muscle development. Double-muscled (DM) cattle have a loss-of-function mutation in their myostatin gene responsible for a hypermuscular phenotype mainly due to hyperplasia. Thus these animals rep...
ORGANISM(S): Bos taurus 
2010-07-01 | E-GEOD-5456 | biostudies-arrayexpress
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