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MetabolomicsAqueous Artemisia argyi extract mitigates acute lung injury in association with coordinated alterations in gut microbiota, metabolic homeostasis, and pulmonary inflammatory gene expression
Background: Artemisia argyi is a traditional medicinal herb with established anti-inflammatory and immunomodulatory properties. Its aqueous extract (AEAA), enriched in water-soluble bioactive constituents, exhibits favorable safety and bioavailability; however, its potential protective effects again...
2026-03-27 | MTBLS14160 | MetaboLights
MetabolomicsAqueous Artemisia argyi extract mitigates acute lung injury in association with coordinated alterations in gut microbiota, metabolic homeostasis, and pulmonary inflammatory gene expression
his study investigated the metabolic alterations in colonic contents associated with aqueous extract of Artemisia argyi (AEAA) intervention in a lipopolysaccharide (LPS)-induced acute lung injury (ALI) mouse model. Male C57BL/6 mice were randomly divided into control, LPS, and AEAA treatment groups ...
2026-03-27 | MTBLS14155 | MetaboLights
MetabolomicsMulti-Omics analyses reveal dynamic interactions between DNA methylation and transcriptional regulation during black raspberry ripening
We show developmental-series transcriptome, methylome, and metabolome to reveal extensive epigenetic reprogramming during black raspberry (Rubus occidentalis) fruit ripening. Multi-omics integration reveals coordinated anthocyanin accumulation parallels expression of biosynthetic and regulatory gene...
2026-09-28 | MTBLS15819 | MetaboLights
MetabolomicsRhizosphere reprogramming by phosphate slag enhances glutathione-centered redox regulation and root development in tobacco

Background and aims: Phosphate slag, a by-product of phosphorus and steel production, is a potential soil amendment that improves nutrient availability and redox stability. However, how it reshapes the rhizosphere microbiome and metabolism to promote tobacco (Nicotiana tabacum L.) root developmen...

2026-01-16 | MTBLS13273 | MetaboLights
TranscriptomicsCoordinated regulation of synthesis and stability of RNA during the acute TNF-induced proinflammatory response
Steady-state gene expression is a coordination of synthesis and decay of RNA through epigenetic regulation, transcription factors, miRNAs, and RNA-binding proteins. Here, we present Bru-Seq and BruChase-Seq to assess genome-wide changes to RNA synthesis and stability in human fibroblasts at homeosta...
ORGANISM(S): Homo sapiens 
2013-01-29 | E-GEOD-43440 | biostudies-arrayexpress
TranscriptomicsCoordinated regulation of neuronal mRNA steady-state levels through developmentally controlled intron retention
Differentiated cells acquire unique structural and functional traits through coordinated expression of lineage-specific genes. An extensive battery of genes encoding components of the synaptic transmission machinery and specialized cytoskeletal proteins is activated during neurogenesis, but the unde...
ORGANISM(S): Mus musculus 
2012-07-12 | E-GEOD-37933 | biostudies-arrayexpress
TranscriptomicsDynamic and Coordinated Epigenetic Regulation of Developmental Transitions in the Cardiac Lineage
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2013-06-15 | E-GEOD-47950 | biostudies-arrayexpress
TranscriptomicsCoordinated regulation of cell cycle transcripts by p53-inducible microRNAs, miR -192 and -215
Cell cycle arrest in response to DNA damage is an important anti-tumorigenic mechanism. microRNAs (miRNAs) were shown recently to play key regulatory roles in cell cycle progression. For example, miR-34a is induced in response to p53 activation and mediates G1 arrest by down-regulating multiple ce...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-13105 | biostudies-arrayexpress
TranscriptomicsCoordinated regulation of MAPK signaling pathway and microRNA in response to ionizing radiation in lung cancer cells
microRNA regulates cellular responses to ionizing radiation (IR) through the translational control of target genes. We analyzed time-series changes in microRNA expressions upon γ-irradiation in H1299 lung cancer cell lines using microarray. Significantly changed microRNAs were selected based on ANOV...
ORGANISM(S): Homo sapiens 
2011-09-13 | E-GEOD-30075 | biostudies-arrayexpress
TranscriptomicsCoordinated regulation of polycomb group complexes through microRNAs in cancer
To determine the altered mRNA expression signatures upon overexpressing EZH2 regulated microRNAs in cancer. To identify EZH2 regulated microRNAs in cancer. Two-condition experiment: Each EZH2 microRNA was overexpressed and compared to a control RNA in BT549 breast cancer cells. In DU145 prostate can...
ORGANISM(S): Homo sapiens 
2011-10-20 | E-GEOD-26996 | biostudies-arrayexpress
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