Coordinated regulation of cell cycle transcripts by p53-inducible microRNAs, miR -192 and -215

ABSTRACT: Cell cycle arrest in response to DNA damage is an important anti-tumorigenic mechanism. microRNAs (miRNAs) were shown recently to play key regulatory roles in cell cycle progression. For example, miR-34a is induced in response to p53 activation and mediates G1 arrest by down-regulating multiple cell cycle-related transcripts. Here we show that genotoxic stress promotes the p53-dependent up-regulation of the homologous miRNAs, miR -192 and miR-215. Like miR-34a, activation of miR-192/215 induces cell cycle arrest suggesting that multiple microRNA families operate in the p53 network. Furthermore, we define a downstream gene expression signature for miR-192/215 expression that includes a number of transcripts that regulate G1 and G2 checkpoints. Of these transcripts, 18 transcripts are

ORGANISM(S): Homo sapiens

SUBMITTER: Aimee Jackson 

PROVIDER: E-GEOD-13105 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress