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ProteomicsA Covalent PFKL Activator Suppresses Tumor Growth
Glycolysis fuels vital cellular functions and its dysregulation is implicated in cancer, neurodegeneration, antibiotic resistance and diabetes. The glycolytic dependency of cancer, known as the Warburg effect, presents a key vulnerability for developing targeted anticancer agents but remains challen...
ORGANISM(S): Homo sapiens (Human) 
2026-06-18 | PXD078921 | Pride
Pfkl Edc Covalent activator Tumor supression Glycolysis 
UnknownA Covalent PFKL Activator Suppresses Tumor Growth.
Not available
S-EPMC12621983 | biostudies-literature
TranscriptomicsCharacterization of RA839, a non-covalent small-molecule binder to Keap1 and selective activator of Nrf2 signalling
The activation of the transcription factor NF-E2-related factor 2 (Nrf2) maintains cellular homeostasis in response to oxidative stress by the regulation of multiple cytoprotective genes. Without stressors the activity of Nrf2 is inhibited by its interaction with the kelch-like ECH-associated protei...
ORGANISM(S): Mus musculus 
2015-10-31 | E-GEOD-71695 | biostudies-arrayexpress
GenomicsTargeting transcriptional dependencies in cancer using a covalent CDK7 inhibitor (ChIP-Seq)
Cyclin-dependent kinase 7 (CDK7) plays a critical role in the general regulation of RNA polymerase II-mediated transcription. However, the absence of selective CDK7 inhibitors has hindered the ability to investigate the consequences of acute and prolonged inhibition of CDK7 under normal and patholo...
ORGANISM(S): Homo sapiens 
2013-12-23 | E-GEOD-50622 | biostudies-arrayexpress
UnknownNon-covalent NRF2 Activation Confers Greater Cellular Protection than Covalent Activation.
Not available
S-EPMC6800637 | biostudies-literature
UnknownSerendipitous Identification of a Covalent Activator of Liver Pyruvate Kinase.
Not available
S-EPMC10099687 | biostudies-literature
TranscriptomicsThe conserved ubiquitin-like protein Hub1 plays a critical role in splicing in human cells
Different from canonical ubiquitin-like proteins, Hub1 does not form covalent conjugates with substrates but binds proteins non-covalently. In Saccharomyces cerevisiae, Hub1 associates with spliceosomes and mediates alternative splicing of SRC1, without affecting pre-mRNA splicing generally. Human H...
ORGANISM(S): Homo sapiens 
2014-05-30 | E-GEOD-56878 | biostudies-arrayexpress
UnknownCovalent Chemical Cochaperones of the p300/CBP GACKIX Domain.
Not available
S-EPMC10900128 | biostudies-literature
UnknownDissecting allosteric effects of activator-coactivator complexes using a covalent small molecule ligand.
Not available
S-EPMC4143068 | biostudies-literature
TranscriptomicsTargeting transcriptional dependencies in cancer using a covalent CDK7 inhibitor (expression)
Cyclin-dependent kinase 7 (CDK7) plays a critical role in the general regulation of RNA polymerase II-mediated transcription. However, the absence of selective CDK7 inhibitors has hindered the ability to investigate the consequences of acute and prolonged inhibition of CDK7 under normal and patholo...
ORGANISM(S): Homo sapiens 
2014-06-22 | E-GEOD-50624 | biostudies-arrayexpress
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