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ProteomicsA Covalent PFKL Activator Suppresses Tumor Growth
Glycolysis fuels vital cellular functions and its dysregulation is implicated in cancer, neurodegeneration, antibiotic resistance and diabetes. The glycolytic dependency of cancer, known as the Warburg effect, presents a key vulnerability for developing targeted anticancer agents but remains challen...
ORGANISM(S): Homo sapiens (Human) 
2026-06-18 | PXD078921 | Pride
Pfkl Edc Covalent activator Tumor supression Glycolysis 
UnknownHDAC6-mediated PFKL deacetylation enhances aerobic glycolysis and promotes VSMC proliferation.
Not available
S-EPMC12828377 | biostudies-literature
UnknownA Covalent PFKL Activator Suppresses Tumor Growth.
Not available
S-EPMC12621983 | biostudies-literature
UnknownSelective activation of PFKL suppresses the phagocytic oxidative burst.
Not available
S-EPMC8802628 | biostudies-literature
UnknownPhosphorylation of PFKL regulates metabolic reprogramming in macrophages following pattern recognition receptor activation.
Not available
S-EPMC11291651 | biostudies-literature
UnknownDNAAF5 promotes hepatocellular carcinoma malignant progression by recruiting USP39 to improve PFKL protein stability.
Not available
S-EPMC9582515 | biostudies-literature
UnknownPFKL/miR-128 axis regulates glycolysis by inhibiting AKT phosphorylation and predicts poor survival in lung cancer.
Not available
S-EPMC4859674 | biostudies-literature
UnknownEGR1 suppresses HCC growth and aerobic glycolysis by transcriptionally downregulating PFKL.
Not available
S-EPMC10823730 | biostudies-literature
UnknownAntitumor effects of the small molecule DMAMCL in neuroblastoma via suppressing aerobic glycolysis and targeting PFKL.
Not available
S-EPMC8613996 | biostudies-literature
UnknownUbiquitin-specific protease 14 targets PFKL-mediated glycolysis to promote the proliferation and migration of oral squamous cell carcinoma.
Not available
S-EPMC10885370 | biostudies-literature
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