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ProteomicsDiscovery of novel CRBN ligands by virtual screening and biological evaluation against multiple hematological cancer cell lines
Immunomodulatory drugs, functioning as cereblon (CRBN) E3 ligase ligands, have been approved for treating various hematological malignancies by hijacking the function of CRBN E3 ligase and inducing the degradation of multiple CRBN-associated substrates. However, the inevitable emergence of drug resi...
ORGANISM(S): Homo sapiens (Human) 
2025-10-13 | PXD061290 | Pride
Hematological cancer  imids  crbn ligands  molecular docking  antitumor evaluation 
UnknownDesign, Synthesis, and Biological Evaluation of HDAC Degraders with CRBN E3 Ligase Ligands.
Not available
S-EPMC8658794 | biostudies-literature
UnknownDiscovery of CRBN-Dependent WEE1 Molecular Glue Degraders from a Multicomponent Combinatorial Library.
Not available
S-EPMC11800961 | biostudies-literature
UnknownDevelopment of Substituted Phenyl Dihydrouracil as the Novel Achiral Cereblon Ligands for Targeted Protein Degradation.
Not available
S-EPMC10398712 | biostudies-literature
UnknownDiscovery of E3 Ligase Ligands for Target Protein Degradation.
Not available
S-EPMC9573645 | biostudies-literature
UnknownDevelopment of Phenyl-substituted Isoindolinone- and Benzimidazole-type Cereblon Ligands for Targeted Protein Degradation.
Not available
S-EPMC10922875 | biostudies-literature
UnknownInfluence of Linker Attachment Points on the Stability and Neosubstrate Degradation of Cereblon Ligands.
Not available
S-EPMC8591746 | biostudies-literature
UnknownDevelopment of a Partial Proteolysis Targeting Chimera Library Based on Achiral Cereblon E3 Ligase Ligands and its Application for Bruton's Tyrosine Kinase Degraders.
Not available
S-EPMC12471865 | biostudies-literature
ProteomicsThe E3 ubiquitin ligase adaptor cereblon targets the C-terminal cyclic imide degron
The E3 ligase factor cereblon (CRBN) is a target of thalidomide and lenalidomide, which are therapeutic agents used in the treatment of hematopoietic malignancies and as ligands for targeted protein degradation. These agents are proposed to mimic a naturally occurring degron; however, the structural...
ORGANISM(S): Homo sapiens (Human) 
2022-07-28 | PXD034248 | Pride
Degron Cyclic imide Cereblon Protac 
UnknownA Facile Protocol for C(sp<sup>2</sup>)-C(sp<sup>3</sup>) Bond Formation Reactions Toward Functionalized E3 Ligase Ligands.
Not available
S-EPMC12913232 | biostudies-literature
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