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ProteomicsCRBN interactions - Protein interaction study using C-terminally tagged Cereblon
Protein interaction study using C-terminally tagged Cereblon
ORGANISM(S): Homo sapiens (Human) 
2016-05-24 | PXD003440 | Pride
Cereblon 
GenomicsCereblon influences the timing of muscle differentiation in Ciona tadpoles
Cereblon influences the timing of muscle differentiation in Ciona tadpoles
PRJNA1010347 | ENA
ProteomicsThe E3 ubiquitin ligase adaptor cereblon targets the C-terminal cyclic imide degron
We identify cyclic imides, previously overlooked post-translation modifications, across different tissues (red blood cells and bovine lens) and human-derived cell lines and found that these modifications are globally regulated by cereblon.
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) 
2022-07-28 | PXD030091 | Pride
Degron Lc-ms/ms Cyclic imide Cereblon Ptm 
TranscriptomicsCereblon expression is required for the anti-myeloma activity of lenalidomide and pomalidomide
This SuperSeries is composed of the following subset Series: GSE31421: Cereblon expression is required for the anti-myeloma activity of lenalidomide and pomalidomide [expression profiling] GSE31451: Cereblon expression is required for the anti-myeloma activity of lenalidomide and pomalidomide [aCGH]...
ORGANISM(S): Homo sapiens 
2011-09-30 | E-GEOD-31452 | biostudies-arrayexpress
UnknownChemical Ligand Space of Cereblon.
Not available
S-EPMC6644994 | biostudies-literature
ProteomicsThe E3 ubiquitin ligase adaptor cereblon targets the C-terminal cyclic imide degron
The E3 ligase factor cereblon (CRBN) is a target of thalidomide and lenalidomide, which are therapeutic agents used in the treatment of hematopoietic malignancies and as ligands for targeted protein degradation. These agents are proposed to mimic a naturally occurring degron; however, the structural...
ORGANISM(S): Homo sapiens (Human) 
2022-07-28 | PXD034248 | Pride
Degron Cyclic imide Cereblon Protac 
TranscriptomicsExpression data from comparison of wild type and cereblon knock out murine T-cells
Thalidomide and other immunomodulatory drugs are effective therapies for certain hematological cancers where they kill tumor cells and stimulate T-cell immunity. These compounds mediate their functions by binding to and altering substrate specificity of cereblon (CRBN), an E3-ubiquitin ligase compon...
ORGANISM(S): Mus musculus 
2020-05-06 | GSE81725 | GEO
UnknownUDP-glucose, cereblon-dependent proinsulin degrader.
Not available
S-EPMC9418190 | biostudies-literature
UnknownCRL4-Cereblon complex in Thalidomide Embryopathy: a translational investigation.
Not available
S-EPMC6972723 | biostudies-literature
ProteomicsThe novel cereblon modulator CC-885 inhibits mitophagy via selective degradation of BNIP3L
Here, by state-of-the-art mass spectrometry-based quantitative proteomic technology, we systematically screened the potential neo-substrates of a novel thalidomide derived cereblon modulator CC-885.
ORGANISM(S): Homo Sapiens 
2020-01-11 | PXD017071 |
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