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TranscriptomicsTranscription profiling of mouse small intestinal crypt-villus axis
Genes encoding transcription factors function as hubs in gene regulatory networks because they encode DNA-binding proteins, which bind to promoters that carry their binding sites. In the present work we have studied gene regulatory networks defined by genes with transcripts belonging to different mR...
ORGANISM(S): Mus musculus 
2008-06-12 | E-GEOD-3216 | biostudies-arrayexpress
TranscriptomicsSingle intestinal stem cells build crypt-villus structures in vitro without a cellular niche
The intestinal epithelium is the most rapidly self-renewing tissue in adult mammals. We have recently demonstrated the presence of approximately six cycling Lgr5+ stem cells at the bottoms of small intestinal crypts1. We have now established long-term culture conditions under which single crypts und...
ORGANISM(S): Mus musculus 
2009-04-03 | E-GEOD-14594 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of jejunums from wild type and Klf9-/- mice to investigate the involvement of Klf9 in small intestine crypt-villus cell renewal and lineage determination.
Kruppel-like factor 9 (Klf9), a zinc-finger transcription factor, is implicated in the control of cell proliferation, cell differentiation and cell fate in brain and uterus. Using Klf9 null mutant mice, we have investigated the involvement of Klf9 in small intestine crypt-villus cell renewal and li...
ORGANISM(S): Mus musculus 
2007-11-15 | E-GEOD-6443 | biostudies-arrayexpress
GenomicsSpatial mapping of telocytes along the crypt-villus axis reveals their role in intestinal homeostasis
Spatial mapping of telocytes along the crypt-villus axis reveals their role in intestinal homeostasis
PRJNA1265722 | ENA
GenomicsRNA Polymerase II Dynamics along the Intestinal Crypt-Villus Axis
RNA Polymerase II Dynamics along the Intestinal Crypt-Villus Axis
PRJNA1026116 | ENA
TranscriptomicsGene regulatory networks along the small intestinal crypt-villus axis
Genes encoding transcription factors function as hubs in gene regulatory networks because they encode DNA-binding proteins, which bind to promoters that carry their binding sites. In the present work we have studied gene regulatory networks defined by genes with transcripts belonging to different mR...
ORGANISM(S): Mus musculus 
2005-11-29 | GSE3216 | GEO
TranscriptomicsSpatial mapping of telocytes along the crypt-villus axis reveals their role in intestinal homeostasis
We employed a single-cell RNA sequencing approach using the 10X Genomics platform to study the diversity of telocyte populations in the mouse jejunum. Telocytes are a unique mesenchymal cell type expressing the transcription factor Foxl1 and forming a subepithelial network along the entire crypt-vil...
ORGANISM(S): Mus musculus 
2026-06-01 | GSE297695 | GEO
TranscriptomicsTranscriptome profiling of T84 colorectal carcinoma cells treated with receptor guanylyl cyclace C agonist (stable toxin)
Receptor guanylyl cyclase C (GC-C) is expressed in the intestinal epithelia and plays a key role in intestinal physiology. Activation of GC-C by its ligands has been shown to regulate proliferation and differentiation of enterocytes along the crypt-villus axis. This study aims to identify genes regu...
ORGANISM(S): Homo sapiens 
2014-02-04 | E-GEOD-45531 | biostudies-arrayexpress
UnknownEnergy metabolism in intestinal epithelial cells during maturation along the crypt-villus axis.
Not available
S-EPMC4997266 | biostudies-literature
UnknownPepT1 Expression Helps Maintain Intestinal Homeostasis by Mediating the Differential Expression of miRNAs along the Crypt-Villus Axis.
Not available
S-EPMC4890533 | biostudies-literature
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